C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Eph receptor A4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026235 Epha4 10090 - 1:77367185-77515088 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027451 Epha4-201 77367185-77515088 protein_coding
  ENSMUST00000186930 Epha4-005 77401223-77515083 protein_coding
  ENSMUST00000187346 Epha4-006 77373613-77377607 protein_coding
  ENSMUST00000188797 Epha4-001 77373139-77515088 protein_coding
  ENSMUST00000188952 Epha4-002 77367189-77515079 nonsense_mediated_decay
  ENSMUST00000189934 Epha4-004 77396797-77515085 retained_intron
  ENSMUST00000190149 Epha4-003 77373631-77515079 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027451ENSMUST00000186930ENSMUST00000187346ENSMUST00000188797ENSMUST00000188952ENSMUST00000189934ENSMUST00000190149
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027451 0.923±0.00 0.122±0.09 1.681±0.00 6.775±3.75 0.297±0.03 0.463±0.13 5.096±0.79 0.415±0.04 0.026±0.01 N/A 0.389±0.00 0.764±0.29 1.266±0.13 0.019±0.01
ENSMUST00000186930 N/A 0.624±0.20 N/A N/A 1.541±0.00 3.968±0.00 N/A N/A 0.104±0.00 N/A N/A 2.708±0.00 N/A N/A
ENSMUST00000187346 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.042±0.00
ENSMUST00000188797 N/A 0.158±0.00 N/A N/A 0.308±0.00 N/A N/A N/A 0.048±0.01 N/A N/A 1.443±0.61 N/A 0.123±0.00
ENSMUST00000188952 1.661±0.46 0.081±0.03 2.195±0.95 14.360±1.71 0.420±0.12 0.784±0.14 5.041±2.68 0.748±0.19 0.119±0.09 3.137±0.90 0.317±0.10 1.027±0.57 0.887±0.50 0.067±0.08
ENSMUST00000189934 N/A 0.093±0.00 N/A N/A 0.170±0.00 0.303±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000190149 1.015±0.24 0.239±0.08 N/A 25.029±0.00 0.442±0.13 0.847±0.22 2.957±0.56 0.647±0.17 0.039±0.01 1.964±0.19 N/A 1.383±0.48 1.607±0.97 0.120±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006O4 CIL_0006O4_0002 CGP 1:75546266-77515088
CIL_0006XL CIL_0006XL_0002 CGP 1:77367185-78197134

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 ISS protein kinase activity
GO:0005004 IMP GPI-linked ephrin receptor activity
GO:0005005 IDA transmembrane-ephrin receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 ISS cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0007155 IEA cell adhesion
GO:0007411 IMP axon guidance
GO:0007628 IMP adult walking behavior
GO:0008045 IMP motor neuron axon guidance
GO:0008347 IEA glial cell migration
GO:0009986 IEA cell surface
GO:0014069 IEA postsynaptic density
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0021957 IMP corticospinal tract morphogenesis
GO:0030054 IEA cell junction
GO:0030175 IEA filopodium
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0031594 IEA neuromuscular junction
GO:0031901 IDA early endosome membrane
GO:0032314 IDA regulation of Rac GTPase activity
GO:0032317 IMP regulation of Rap GTPase activity
GO:0032319 IEA regulation of Rho GTPase activity
GO:0042731 IEA PH domain binding
GO:0042802 IPI identical protein binding
GO:0042995 IEA cell projection
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043679 IEA axon terminus
GO:0044295 IEA axonal growth cone
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0046777 ISS protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048013 IEA ephrin receptor signaling pathway
GO:0048681 IMP negative regulation of axon regeneration
GO:0048710 IMP regulation of astrocyte differentiation
GO:0050770 IMP regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0061001 IMP regulation of dendritic spine morphogenesis
GO:0097155 IMP fasciculation of sensory neuron axon
GO:0097156 IMP fasciculation of motor neuron axon
GO:0097161 ISS DH domain binding
GO:2001108 ISS positive regulation of Rho guanyl-nucleotide exchange factor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010767 epha4l eph receptor A4, like protein_coding Danio_rerio
ENSDARG00000054454 epha4a eph receptor A4a protein_coding Danio_rerio
ENSG00000116106 EPHA4 EPH receptor A4 protein_coding Homo_sapiens

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