C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: EPH receptor A4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116106 EPHA4 9606 - 2:221418027-221574202 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000281821 EPHA4-201 221418029-221572290 protein_coding
  ENST00000409854 EPHA4-003 221425599-221572283 protein_coding
  ENST00000409938 EPHA4-001 221425901-221574202 protein_coding
  ENST00000415749 EPHA4-013 221563993-221572300 nonsense_mediated_decay
  ENST00000419964 EPHA4-005 221563997-221569481 protein_coding
  ENST00000424339 EPHA4-009 221425915-221434249 nonsense_mediated_decay
  ENST00000434266 EPHA4-004 221564279-221574158 protein_coding
  ENST00000441679 EPHA4-006 221457954-221502560 protein_coding
  ENST00000443796 EPHA4-012 221457889-221572300 protein_coding
  ENST00000463446 EPHA4-007 221482440-221501344 retained_intron
  ENST00000469354 EPHA4-014 221418027-221425575 processed_transcript
  ENST00000472696 EPHA4-015 221420445-221425540 processed_transcript
  ENST00000495693 EPHA4-008 221436457-221437496 retained_intron
  ENST00000541600 EPHA4-002 221564106-221572358 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000281821ENST00000409854ENST00000409938ENST00000419964ENST00000443796ENST00000469354ENST00000472696
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000281821 1.331±0.00 1.477±0.00 10.231±0.99 0.723±0.00 1.217±0.82 1.892±1.11 1.152±0.00 N/A 0.657±0.00 0.729±0.00 1.301±0.67 0.229±0.00 2.891±1.52
ENST00000409854 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.257±0.00 N/A N/A
ENST00000409938 N/A N/A 6.296±0.00 N/A 1.604±0.00 0.994±0.00 0.079±0.00 1.355±0.00 1.902±0.00 0.174±0.00 0.988±0.00 0.194±0.00 3.916±0.00
ENST00000419964 N/A N/A N/A N/A N/A N/A N/A N/A 3.319±0.00 N/A N/A N/A N/A
ENST00000443796 N/A N/A N/A N/A N/A N/A 0.724±0.00 N/A N/A N/A N/A N/A N/A
ENST00000469354 N/A N/A 4.725±0.00 0.620±0.00 1.596±0.00 N/A 0.262±0.23 N/A 1.332±0.00 N/A 1.992±0.69 0.255±0.06 4.182±0.00
ENST00000472696 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.519±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006O4 CIL_0006O4_0001 CGP 2:219627327-221574202
CIL_0006XL CIL_0006XL_0001 CGP 2:221418027-222298996

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005003 IEA ephrin receptor activity
GO:0005004 ISS GPI-linked ephrin receptor activity
GO:0005005 ISS transmembrane-ephrin receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 ISS cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0005887 ISS:IEA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007155 IEA cell adhesion
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 IEA axon guidance
GO:0007628 IEA adult walking behavior
GO:0008045 ISS motor neuron axon guidance
GO:0008347 IEA glial cell migration
GO:0009986 IEA cell surface
GO:0014069 IEA postsynaptic density
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA:IDA peptidyl-tyrosine phosphorylation
GO:0021957 ISS corticospinal tract morphogenesis
GO:0030054 IEA cell junction
GO:0030175 IEA filopodium
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031594 IEA neuromuscular junction
GO:0031901 ISS early endosome membrane
GO:0032314 ISS regulation of Rac GTPase activity
GO:0032317 ISS regulation of Rap GTPase activity
GO:0032319 IEA regulation of Rho GTPase activity
GO:0042731 IPI PH domain binding
GO:0042802 IEA identical protein binding
GO:0042995 IEA cell projection
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0043679 IEA axon terminus
GO:0044295 IEA axonal growth cone
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0046777 IDA protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048013 IEA ephrin receptor signaling pathway
GO:0048681 ISS negative regulation of axon regeneration
GO:0048710 ISS regulation of astrocyte differentiation
GO:0050770 ISS regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0061001 ISS regulation of dendritic spine morphogenesis
GO:0097155 ISS fasciculation of sensory neuron axon
GO:0097156 ISS fasciculation of motor neuron axon
GO:0097161 IDA DH domain binding
GO:2001108 IDA positive regulation of Rho guanyl-nucleotide exchange factor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010767 epha4l eph receptor A4, like protein_coding Danio_rerio
ENSDARG00000054454 epha4a eph receptor A4a protein_coding Danio_rerio
ENSMUSG00000026235 Epha4 Eph receptor A4 protein_coding Mus_musculus

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