C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin alpha 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027009 Itga4 10090 + 2:79255426-79333123 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000099972 Itga4-001 79255500-79333123 protein_coding
  ENSMUST00000126312 Itga4-005 79255947-79292977 processed_transcript
  ENSMUST00000135919 Itga4-004 79255721-79293273 processed_transcript
  ENSMUST00000141094 Itga4-003 79255572-79273986 processed_transcript
  ENSMUST00000155105 Itga4-002 79255426-79257852 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000099972ENSMUST00000141094
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000099972 1.030±0.52 0.314±0.11 1.293±0.18 1.023±0.23 4.605±1.27 1.149±0.30 0.499±0.19 0.536±0.09 5.215±5.94 3.610±0.48 0.569±0.17 0.932±0.42 0.874±0.39 0.133±0.02
ENSMUST00000141094 N/A 0.407±0.07 N/A N/A N/A 1.678±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BZ CIL_0004BZ_0003 CGP 2:78868124-79333123
CIL_00080Y CIL_00080Y_0002 VISTA 2:79161477-79762272
CIL_0004C0 CIL_0004C0_0003 CGP 2:79255426-79456785

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001968 IMP fibronectin binding
GO:0001974 IMP blood vessel remodeling
GO:0003366 IEA cell-matrix adhesion involved in ameboidal cell migration
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005925 IEA focal adhesion
GO:0007155 IMP cell adhesion
GO:0007157 IMP heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IMP leukocyte cell-cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007507 IMP heart development
GO:0008305 IEA integrin complex
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0016020 IEA membrane
GO:0016477 IMP cell migration
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0034669 IEA integrin alpha4-beta7 complex
GO:0035987 IEA endodermal cell differentiation
GO:0043113 IEA receptor clustering
GO:0050839 IEA cell adhesion molecule binding
GO:0050901 IEA leukocyte tethering or rolling
GO:0060324 IMP face development
GO:0060710 IMP chorio-allantoic fusion
GO:0070062 IEA extracellular vesicular exosome
GO:0072678 IMP T cell migration
GO:0090074 IEA negative regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061186 itga4 integrin alpha 4 protein_coding Danio_rerio
ENSG00000115232 ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) protein_coding Homo_sapiens

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