C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115232 ITGA4 9606 + 2:181457202-181536187 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233573 ITGA4-006 181457428-181509805 protein_coding
  ENST00000339307 ITGA4-003 181457207-181476218 protein_coding
  ENST00000397033 ITGA4-001 181457225-181536187 protein_coding
  ENST00000465522 ITGA4-004 181457404-181486309 retained_intron
  ENST00000468948 ITGA4-011 181523335-181524365 retained_intron
  ENST00000473002 ITGA4-010 181493034-181495832 retained_intron
  ENST00000476089 ITGA4-002 181457202-181459391 retained_intron
  ENST00000476824 ITGA4-008 181498572-181527450 retained_intron
  ENST00000478440 ITGA4-005 181458241-181479716 processed_transcript
  ENST00000484404 ITGA4-007 181457713-181475290 retained_intron
  ENST00000490435 ITGA4-009 181498281-181511771 retained_intron
  ENST00000614742 ITGA4-201 181457225-181535562 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000233573ENST00000397033ENST00000476824ENST00000484404ENST00000614742
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000233573 N/A N/A 0.324±0.00 N/A N/A N/A 0.540±0.00 0.724±0.00 2.131±0.00 6.093±0.00 N/A 1.516±0.00 N/A N/A
ENST00000397033 0.411±0.00 5.097±0.00 0.135±0.00 0.130±0.00 0.402±0.00 1.229±0.90 N/A 0.626±0.09 N/A 5.379±0.89 N/A 0.306±0.05 1.132±0.34 N/A
ENST00000476824 N/A N/A N/A N/A N/A 4.201±0.00 N/A 1.636±0.00 N/A N/A 0.116±0.00 N/A N/A N/A
ENST00000484404 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.503±0.00 N/A N/A N/A
ENST00000614742 N/A N/A N/A N/A N/A 1.377±0.00 0.230±0.00 N/A N/A N/A N/A 1.676±0.27 3.272±0.00 0.384±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BZ CIL_0004BZ_0002 CGP 2:180967248-181536187
CIL_00080Y CIL_00080Y_0001 VISTA 2:181386314-181987082
CIL_0004C0 CIL_0004C0_0002 CGP 2:181457202-181680665

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001968 IEA fibronectin binding
GO:0001974 IEA blood vessel remodeling
GO:0003366 IMP cell-matrix adhesion involved in ameboidal cell migration
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0007155 IEA cell adhesion
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008305 IEA integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016477 IEA cell migration
GO:0030183 IC B cell differentiation
GO:0030198 TAS extracellular matrix organization
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0034669 IDA integrin alpha4-beta7 complex
GO:0035987 IEP endodermal cell differentiation
GO:0043113 IMP receptor clustering
GO:0046872 IEA metal ion binding
GO:0050776 TAS regulation of immune response
GO:0050839 IPI cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0050901 IMP leukocyte tethering or rolling
GO:0060324 IEA face development
GO:0060710 IEA chorio-allantoic fusion
GO:0070062 IDA extracellular vesicular exosome
GO:0072678 IEA T cell migration
GO:0090074 IDA negative regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061186 itga4 integrin alpha 4 protein_coding Danio_rerio
ENSMUSG00000027009 Itga4 integrin alpha 4 protein_coding Mus_musculus

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