C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: itchy, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000109685 Itch-002 ENSMUSG00000027598 10090 + 2:155133559-155226853 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainLiverMuscleOvaryPlacentaTestisENSMUST00000109685
Transcript ID Adrenal Bladder Brain Liver Muscle Ovary Placenta Testis
ENSMUST00000109685 0.909±0.00 1.160±0.00 1.794±0.47 0.760±0.12 0.791±0.21 1.274±0.43 2.109±1.07 0.873±0.40

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098F CIL_00098F_0002 VISTA 2:154750090-155352094
CIL_0003SW CIL_0003SW_0002 CGP 2:155059310-155226855
CIL_0005BA CIL_0005BA_0002 CGP 2:155133509-155250277

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000151 ISA ubiquitin ligase complex
GO:0000209 IDA protein polyubiquitination
GO:0002669 IMP positive regulation of T cell anergy
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005938 IDA cell cortex
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006915 IEA apoptotic process
GO:0016020 IDA membrane
GO:0016567 ISS protein ubiquitination
GO:0016874 IMP ligase activity
GO:0031410 IDA cytoplasmic vesicle
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0035519 ISS protein K29-linked ubiquitination
GO:0042787 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043021 IEA ribonucleoprotein complex binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0045087 IEA innate immune response
GO:0045236 IEA CXCR chemokine receptor binding
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046329 IMP negative regulation of JNK cascade
GO:0046642 IMP negative regulation of alpha-beta T cell proliferation
GO:0050687 IMP negative regulation of defense response to virus
GO:0051607 IEA defense response to virus
GO:0070062 IEA extracellular vesicular exosome
GO:0070534 ISS protein K63-linked ubiquitination
GO:0070936 ISS protein K48-linked ubiquitination
GO:0090085 IMP regulation of protein deubiquitination

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000262650 ITCH-002 protein_coding Homo_sapiens 0 2985
ENST00000374864 ITCH-001 protein_coding Homo_sapiens 0 3725
ENST00000461661 ITCH-007 processed_transcript Homo_sapiens 0 521
ENST00000483727 ITCH-005 processed_transcript Homo_sapiens 0 872
ENST00000486883 ITCH-003 processed_transcript Homo_sapiens 0 649
ENST00000535650 ITCH-201 protein_coding Homo_sapiens 0 3415
ENST00000610336 ITCH-202 protein_coding Homo_sapiens 0 3729
ENST00000621101 ITCH-203 protein_coding Homo_sapiens 0 3085

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