C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: profilin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027805 Pfn2 10090 - 3:57841895-57847564 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066882 Pfn2-001 57841895-57847564 protein_coding
  ENSMUST00000119344 Pfn2-002 57841905-57847145 protein_coding
  ENSMUST00000120289 Pfn2-003 57844670-57847489 protein_coding
  ENSMUST00000122210 Pfn2-004 57843108-57845878 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066882ENSMUST00000119344ENSMUST00000120289ENSMUST00000122210
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066882 14.856±9.98 23.866±1.74 40.447±7.72 176.007±50.89 8.344±3.84 3.133±0.64 18.078±1.27 25.112±2.08 1.820±0.97 7.443±1.48 78.004±6.32 22.770±5.67 6.050±3.40 54.690±19.13
ENSMUST00000119344 0.721±0.00 N/A N/A N/A 5.840±6.97 N/A 2.241±0.00 N/A 0.211±0.00 0.915±0.00 16.774±2.07 2.230±0.08 N/A N/A
ENSMUST00000120289 N/A N/A N/A 56.810±0.00 N/A N/A N/A N/A 0.344±0.00 N/A N/A N/A 1.738±0.45 N/A
ENSMUST00000122210 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 14.982±0.00 2.743±0.00 99.027±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002R5 CIL_0002R5_0002 CGP 3:57736066-57847564
CIL_0002QZ CIL_0002QZ_0002 CGP 3:57841895-58466787

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000774 IEA adenyl-nucleotide exchange factor activity
GO:0003779 IEA actin binding
GO:0003785 IEA actin monomer binding
GO:0005515 IPI protein binding
GO:0005546 IEA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0010633 IMP negative regulation of epithelial cell migration
GO:0030036 IEA actin cytoskeleton organization
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0032233 IEA positive regulation of actin filament bundle assembly
GO:0032781 IEA positive regulation of ATPase activity
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0043195 IDA terminal bouton
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0070062 IEA extracellular vesicular exosome
GO:1900028 IMP negative regulation of ruffle assembly
GO:2000300 IMP regulation of synaptic vesicle exocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012682 pfn2l profilin 2 like protein_coding Danio_rerio
ENSG00000070087 PFN2 profilin 2 protein_coding Homo_sapiens

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