C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: profilin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000070087 PFN2 9606 - 3:149964904-150050788 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000239940 PFN2-001 149964904-149971109 protein_coding
  ENST00000423691 PFN2-003 149964913-149970922 protein_coding
  ENST00000452853 PFN2-002 149964904-149970950 protein_coding
  ENST00000460404 PFN2-004 149965689-149970904 nonsense_mediated_decay
  ENST00000461868 PFN2-009 149968154-149970940 protein_coding
  ENST00000461930 PFN2-011 149968118-149970904 protein_coding
  ENST00000468323 PFN2-012 149965713-149970898 nonsense_mediated_decay
  ENST00000475518 PFN2-015 149966260-149970735 protein_coding
  ENST00000481275 PFN2-016 149966268-149970401 protein_coding
  ENST00000481767 PFN2-006 149964935-149970715 protein_coding
  ENST00000489155 PFN2-007 149966316-149971223 protein_coding
  ENST00000490975 PFN2-010 149966078-149970925 protein_coding
  ENST00000494827 PFN2-019 149965857-150022811 protein_coding
  ENST00000497060 PFN2-017 149966053-149968905 retained_intron
  ENST00000497148 PFN2-018 149966161-150050788 protein_coding
  ENST00000498169 PFN2-013 149966251-149970882 nonsense_mediated_decay
  ENST00000498307 PFN2-008 149966285-149971213 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000239940ENST00000423691ENST00000452853ENST00000468323
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000239940 N/A 3.900±0.00 N/A 66.812±40.77 N/A 6.587±2.54 12.312±0.00 17.896±0.00 5.513±0.00 26.126±20.26 12.282±3.98 11.866±0.00 10.825±0.21
ENST00000423691 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.212±0.00 22.173±0.00 16.168±0.00
ENST00000452853 21.192±0.00 5.095±0.00 4.608±0.00 50.143±0.00 19.458±0.00 15.769±0.00 N/A 30.098±0.00 11.827±0.00 N/A 18.626±7.57 7.727±2.04 24.536±0.00
ENST00000468323 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.397±0.00 N/A 15.835±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002R7 CIL_0002R7_0001 CGP 3:149738470-149968385
CIL_0002R6 CIL_0002R6_0001 CGP 3:149761105-149968385
CIL_0002R5 CIL_0002R5_0001 CGP 3:149812708-150050788
CIL_0002QZ CIL_0002QZ_0001 CGP 3:149964904-150466431

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000774 IDA adenyl-nucleotide exchange factor activity
GO:0003779 IEA actin binding
GO:0003785 IPI actin monomer binding
GO:0005515 IPI protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0010633 IMP negative regulation of epithelial cell migration
GO:0030036 IEA actin cytoskeleton organization
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0032233 IMP positive regulation of actin filament bundle assembly
GO:0032781 IDA positive regulation of ATPase activity
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0043195 IEA terminal bouton
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0070062 IDA extracellular vesicular exosome
GO:1900028 IMP negative regulation of ruffle assembly
GO:2000300 IEA regulation of synaptic vesicle exocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012682 pfn2l profilin 2 like protein_coding Danio_rerio
ENSMUSG00000027805 Pfn2 profilin 2 protein_coding Mus_musculus

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