C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paxillin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029528 Pxn 10090 + 5:115506676-115555987 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067268 Pxn-001 115506676-115555987 protein_coding
  ENSMUST00000086523 Pxn-002 115506808-115554978 protein_coding
  ENSMUST00000125007 Pxn-004 115520305-115555982 processed_transcript
  ENSMUST00000125054 Pxn-003 115544796-115549756 retained_intron
  ENSMUST00000127345 Pxn-010 115544085-115544906 processed_transcript
  ENSMUST00000129897 Pxn-006 115516355-115544883 processed_transcript
  ENSMUST00000134198 Pxn-013 115544114-115544948 processed_transcript
  ENSMUST00000137716 Pxn-007 115542914-115546880 processed_transcript
  ENSMUST00000138139 Pxn-012 115551939-115552792 retained_intron
  ENSMUST00000139834 Pxn-011 115545304-115545775 processed_transcript
  ENSMUST00000152156 Pxn-005 115506711-115555982 retained_intron
  ENSMUST00000153682 Pxn-009 115543947-115545412 processed_transcript
  ENSMUST00000157050 Pxn-008 115542950-115546835 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067268ENSMUST00000086523ENSMUST00000125054ENSMUST00000152156
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067268 26.337±2.60 19.816±2.41 23.863±6.64 7.687±4.41 31.478±13.36 36.465±13.52 11.662±2.26 37.983±8.75 13.723±1.42 54.358±5.74 12.131±4.69 23.237±10.18 20.473±10.80 27.982±1.04
ENSMUST00000086523 6.467±0.35 4.935±1.44 N/A 3.440±1.43 11.329±0.84 18.461±5.87 N/A N/A N/A 20.432±4.67 N/A 7.241±2.10 11.590±6.27 6.897±2.62
ENSMUST00000125054 N/A N/A N/A 0.824±0.00 2.074±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000152156 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.528±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZA CIL_0007ZA_0002 VISTA 5:114966986-115567561
CIL_0009CQ CIL_0009CQ_0002 VISTA 5:115188390-115791906

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001725 IEA stress fiber
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005925 IDA focal adhesion
GO:0006928 IMP cellular component movement
GO:0007010 IMP cytoskeleton organization
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007229 IMP integrin-mediated signaling pathway
GO:0008013 IEA beta-catenin binding
GO:0008270 IEA zinc ion binding
GO:0008360 IMP regulation of cell shape
GO:0017166 IEA vinculin binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030032 IDA lamellipodium assembly
GO:0030159 TAS receptor signaling complex scaffold activity
GO:0031252 IDA cell leading edge
GO:0032403 IEA protein complex binding
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0034614 IEA cellular response to reactive oxygen species
GO:0045860 IMP positive regulation of protein kinase activity
GO:0048041 IDA focal adhesion assembly
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0051435 IPI BH4 domain binding
GO:0060396 IEA growth hormone receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060766 PXN (1 of 3) paxillin protein_coding Danio_rerio
ENSG00000089159 PXN paxillin protein_coding Homo_sapiens

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