C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paxillin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000089159 PXN 9606 - 12:120210439-120265771 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000228307 PXN-001 120210447-120265771 protein_coding
  ENST00000267257 PXN-201 120210439-120265771 protein_coding
  ENST00000323871 PXN-005 120210451-120265718 retained_intron
  ENST00000424649 PXN-002 120210447-120265771 protein_coding
  ENST00000440827 PXN-011 120223720-120265706 processed_transcript
  ENST00000458477 PXN-003 120210447-120250161 protein_coding
  ENST00000536957 PXN-004 120210448-120226844 protein_coding
  ENST00000538144 PXN-006 120212314-120224377 processed_transcript
  ENST00000540221 PXN-010 120224175-120226499 processed_transcript
  ENST00000543331 PXN-009 120222717-120226795 protein_coding
  ENST00000546532 PXN-013 120222734-120226055 protein_coding
  ENST00000547746 PXN-018 120224154-120265692 processed_transcript
  ENST00000547772 PXN-016 120226655-120265737 processed_transcript
  ENST00000547983 PXN-017 120221643-120265737 nonsense_mediated_decay
  ENST00000548912 PXN-012 120222737-120226069 protein_coding
  ENST00000550205 PXN-020 120226606-120248750 processed_transcript
  ENST00000550795 PXN-015 120214836-120216006 protein_coding
  ENST00000551327 PXN-021 120222676-120248748 processed_transcript
  ENST00000552550 PXN-014 120222863-120224750 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000228307ENST00000267257ENST00000323871ENST00000424649ENST00000458477ENST00000536957
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000228307 N/A N/A N/A N/A N/A N/A 8.455±0.00 4.660±0.00 1.158±0.00 7.201±0.00 5.205±2.11 25.479±2.23 N/A
ENST00000267257 N/A 8.367±0.00 0.220±0.00 5.831±0.00 2.019±0.00 2.005±1.58 N/A 1.930±0.00 23.531±0.00 N/A 10.069±0.00 N/A N/A
ENST00000323871 N/A 6.230±0.00 N/A 4.321±0.00 N/A 4.106±0.00 N/A N/A 9.323±0.00 7.030±5.39 5.146±2.17 N/A 2.913±0.00
ENST00000424649 33.907±0.00 10.354±0.00 8.221±0.00 6.533±4.05 9.252±8.41 8.055±0.00 4.839±3.66 1.625±0.00 21.847±0.00 N/A 14.088±10.26 46.959±9.06 13.889±1.17
ENST00000458477 N/A N/A N/A N/A N/A 0.845±0.00 N/A 1.882±0.00 N/A N/A N/A N/A N/A
ENST00000536957 15.193±0.00 N/A N/A 0.945±0.00 N/A 2.383±0.00 N/A N/A 6.011±5.38 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009CQ CIL_0009CQ_0001 VISTA 12:119991644-120595694

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001725 IDA stress fiber
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0005875 TAS microtubule associated complex
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0006928 IEA cellular component movement
GO:0006936 TAS muscle contraction
GO:0007010 IEA cytoskeleton organization
GO:0007155 NAS cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007165 TAS signal transduction
GO:0007172 TAS signal complex assembly
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008013 IPI beta-catenin binding
GO:0008270 IEA zinc ion binding
GO:0008360 IEA regulation of cell shape
GO:0017166 IPI vinculin binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030032 IEA lamellipodium assembly
GO:0031252 IEA cell leading edge
GO:0032403 IEA protein complex binding
GO:0034329 TAS cell junction assembly
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0034614 IEP cellular response to reactive oxygen species
GO:0045860 IEA positive regulation of protein kinase activity
GO:0048041 IEA focal adhesion assembly
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0051435 IEA BH4 domain binding
GO:0060396 IDA growth hormone receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060766 PXN (1 of 3) paxillin protein_coding Danio_rerio
ENSMUSG00000029528 Pxn paxillin protein_coding Mus_musculus

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