C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: integrin alpha L
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000106306 Itgal-001 ENSMUSG00000030830 10090 + 7:127296291-127335137 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000106306
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000106306 1.279±0.54 0.679±0.22 0.591±0.16 9.816±3.41 1.438±0.35 0.850±0.42 1.131±0.38 2.005±0.80 8.675±0.93 0.037±0.00 1.032±0.50 0.219±0.06 0.133±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000U7 CIL_0000U7_0002 CGP 7:127296260-127345314

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001772 IDA immunological synapse
GO:0002291 IEA T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005515 IEA protein binding
GO:0005911 IDA cell-cell junction
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008305 IEA integrin complex
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0016020 IEA membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022407 IDA regulation of cell-cell adhesion
GO:0022409 IMP positive regulation of cell-cell adhesion
GO:0030369 IEA ICAM-3 receptor activity
GO:0032403 IEA protein complex binding
GO:0034687 IEA integrin alphaL-beta2 complex
GO:0042102 IMP positive regulation of T cell proliferation
GO:0043113 IEA receptor clustering
GO:0046982 IEA protein heterodimerization activity
GO:0050798 IMP activated T cell proliferation
GO:0050839 IEA cell adhesion molecule binding
GO:0050850 IDA positive regulation of calcium-mediated signaling
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000356798 ITGAL-001 protein_coding Homo_sapiens 0 2241
ENST00000358164 ITGAL-002 protein_coding Homo_sapiens 0 1958
ENST00000433423 ITGAL-004 protein_coding Homo_sapiens 0 547
ENST00000564632 ITGAL-023 retained_intron Homo_sapiens 4.99997e-41 172
ENST00000568987 ITGAL-018 retained_intron Homo_sapiens 7e-27 124

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