C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, pyrin domain containing 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000079476 Nlrp3-001 ENSMUSG00000032691 10090 + 11:59541568-59566955 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079476
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079476 0.215±0.07 0.191±0.06 0.113±0.03 0.130±0.04 0.350±0.01 0.149±0.05 0.125±0.03 0.169±0.04 0.226±0.11 0.490±0.05 0.014±0.00 0.443±0.09 0.097±0.03 0.036±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006TS CIL_0006TS_0002 CGP 11:59485520-59566956
CIL_0006TJ CIL_0006TJ_0002 CGP 11:59541568-59571738

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 ISS inflammatory response
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032611 IMP interleukin-1 beta production
GO:0032621 IMP interleukin-18 production
GO:0042347 ISS negative regulation of NF-kappaB import into nucleus
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546 IMP NLRP3 inflammasome complex assembly
GO:0050701 IMP interleukin-1 secretion
GO:0050718 IGI:ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IMP regulation of inflammatory response
GO:0051607 IMP defense response to virus
GO:0072559 ISS NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000336119 NLRP3-001 protein_coding Homo_sapiens 0 2527
ENST00000348069 NLRP3-002 protein_coding Homo_sapiens 0 1714
ENST00000366496 NLRP3-007 protein_coding Homo_sapiens 0 2043
ENST00000366497 NLRP3-201 protein_coding Homo_sapiens 0 2043
ENST00000391827 NLRP3-004 protein_coding Homo_sapiens 0 1701
ENST00000391828 NLRP3-003 protein_coding Homo_sapiens 0 2593
ENST00000474792 NLRP3-005 processed_transcript Homo_sapiens 0 1714

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