C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, pyrin domain containing 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000101148 Nlrp3-201 ENSMUSG00000032691 10090 + 11:59542686-59566956 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastKidneyLiverLungMuscleOvaryPlacentaENSMUST00000101148
Transcript ID Bladder Breast Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000101148 0.124±0.06 0.316±0.19 0.190±0.00 0.285±0.12 0.616±0.29 0.033±0.00 0.431±0.11 0.081±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006TS CIL_0006TS_0002 CGP 11:59485520-59566956
CIL_0006TJ CIL_0006TJ_0002 CGP 11:59541568-59571738

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002674 IEA negative regulation of acute inflammatory response
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 ISS inflammatory response
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032611 IMP interleukin-1 beta production
GO:0032621 IMP interleukin-18 production
GO:0042347 ISS negative regulation of NF-kappaB import into nucleus
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546 IMP NLRP3 inflammasome complex assembly
GO:0050701 IMP interleukin-1 secretion
GO:0050713 IEA negative regulation of interleukin-1 beta secretion
GO:0050718 IGI:ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050728 IEA negative regulation of inflammatory response
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IMP defense response to virus
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0072559 ISS NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000336119 NLRP3-001 protein_coding Homo_sapiens 0 2527
ENST00000348069 NLRP3-002 protein_coding Homo_sapiens 0 1714
ENST00000366496 NLRP3-007 protein_coding Homo_sapiens 0 2043
ENST00000366497 NLRP3-201 protein_coding Homo_sapiens 0 2043
ENST00000391827 NLRP3-004 protein_coding Homo_sapiens 0 1701
ENST00000391828 NLRP3-003 protein_coding Homo_sapiens 0 2582
ENST00000474792 NLRP3-005 processed_transcript Homo_sapiens 0 1714

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