C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: presenilin associated, rhomboid-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000033918 Parl 10090 - 16:20279820-20302387 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048642 Parl-001 20279820-20302387 protein_coding
  ENSMUST00000123070 Parl-003 20282744-20302340 retained_intron
  ENSMUST00000126001 Parl-008 20285528-20288240 retained_intron
  ENSMUST00000133153 Parl-009 20286956-20302354 nonsense_mediated_decay
  ENSMUST00000136252 Parl-002 20279820-20302345 nonsense_mediated_decay
  ENSMUST00000136700 Parl-005 20286930-20301329 processed_transcript
  ENSMUST00000143648 Parl-006 20292920-20298165 retained_intron
  ENSMUST00000152887 Parl-004 20297597-20301813 processed_transcript
  ENSMUST00000153275 Parl-010 20298124-20302361 retained_intron
  ENSMUST00000155832 Parl-007 20280003-20283244 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000048642ENSMUST00000123070ENSMUST00000136252ENSMUST00000136700ENSMUST00000153275ENSMUST00000155832
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000048642 15.016±2.16 9.237±3.68 28.777±2.56 15.126±4.65 10.299±3.09 11.564±2.34 20.322±1.38 25.724±3.15 15.800±3.02 11.083±1.14 15.664±0.88 11.561±2.49 13.799±4.84 11.982±5.96
ENSMUST00000123070 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.646±0.00 N/A N/A
ENSMUST00000136252 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.037±0.00 N/A N/A 5.758±0.23
ENSMUST00000136700 N/A 8.181±0.34 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000153275 N/A 14.908±5.10 N/A N/A N/A 8.661±3.50 N/A N/A 11.145±2.85 8.138±0.10 N/A N/A 16.795±0.00 N/A
ENSMUST00000155832 N/A 4.844±0.00 N/A 17.006±0.00 N/A N/A N/A N/A N/A N/A N/A 39.449±0.00 25.093±14.88 18.134±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005G0 CIL_0005G0_0002 CGP 16:20233310-20302387

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IMP endopeptidase activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005739 IDA mitochondrion
GO:0005743 IMP mitochondrial inner membrane
GO:0006508 IMP proteolysis
GO:0016021 IEA integral component of membrane
GO:0090201 IMP negative regulation of release of cytochrome c from mitochondria
GO:2000377 IEA regulation of reactive oxygen species metabolic process
GO:2001243 IMP negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020891 PARL (1 of 2) presenilin associated, rhomboid-like protein_coding Danio_rerio
ENSDARG00000039310 parla presenilin associated, rhomboid-like a protein_coding Danio_rerio
ENSG00000175193 PARL presenilin associated, rhomboid-like protein_coding Homo_sapiens

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