C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: presenilin associated, rhomboid-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175193 PARL 9606 - 3:183829385-183884933 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311101 PARL-002 183829390-183884888 protein_coding
  ENST00000317096 PARL-001 183829385-183884907 protein_coding
  ENST00000417784 PARL-009 183829390-183844274 protein_coding
  ENST00000418450 PARL-010 183829390-183842354 protein_coding
  ENST00000421484 PARL-004 183829509-183884908 nonsense_mediated_decay
  ENST00000435888 PARL-007 183829397-183884855 protein_coding
  ENST00000449306 PARL-005 183833768-183884727 protein_coding
  ENST00000450375 PARL-008 183829390-183842394 protein_coding
  ENST00000469056 PARL-003 183862607-183884933 retained_intron
  ENST00000488202 PARL-006 183840570-183844774 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311101ENST00000317096ENST00000417784ENST00000418450ENST00000421484ENST00000435888ENST00000469056
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311101 9.576±0.00 7.839±0.00 2.990±0.00 7.945±0.00 13.805±0.00 12.006±0.00 3.314±2.77 3.003±2.26 4.304±1.48 5.940±0.57 4.459±1.06 6.251±3.44 4.791±0.90 8.418±1.82
ENST00000317096 15.492±0.00 14.896±0.00 N/A 8.240±3.94 16.495±0.00 4.886±0.55 6.212±4.80 6.816±0.00 3.809±1.12 6.084±0.00 8.382±0.00 16.028±3.47 15.070±5.91 8.095±0.48
ENST00000417784 N/A 12.565±0.00 2.594±0.00 N/A 4.693±0.00 N/A N/A 8.910±0.00 4.089±0.00 N/A 4.832±0.00 9.059±0.00 7.401±0.00 N/A
ENST00000418450 N/A 12.494±0.00 N/A N/A N/A 9.933±0.00 N/A 8.520±0.00 8.567±0.00 4.492±0.00 N/A 16.982±7.32 7.862±0.00 12.349±1.24
ENST00000421484 N/A N/A N/A 1.427±0.00 2.613±0.00 N/A N/A N/A N/A N/A N/A 1.081±0.00 N/A N/A
ENST00000435888 N/A N/A N/A N/A N/A N/A N/A 0.529±0.00 N/A N/A N/A N/A 3.896±0.00 N/A
ENST00000469056 N/A N/A N/A N/A N/A N/A N/A 1.582±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005G0 CIL_0005G0_0001 CGP 3:183815876-183884933

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IGI endopeptidase activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005739 IDA mitochondrion
GO:0005743 TAS mitochondrial inner membrane
GO:0006508 IGI proteolysis
GO:0016021 IEA integral component of membrane
GO:0033619 NAS membrane protein proteolysis
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:1903214 NAS regulation of protein targeting to mitochondrion
GO:2000377 IMP regulation of reactive oxygen species metabolic process
GO:2001243 IEA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020891 PARL (1 of 2) presenilin associated, rhomboid-like protein_coding Danio_rerio
ENSDARG00000039310 parla presenilin associated, rhomboid-like a protein_coding Danio_rerio
ENSMUSG00000033918 Parl presenilin associated, rhomboid-like protein_coding Mus_musculus

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