C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: maternal embryonic leucine zipper kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000045607 Melk-001 ENSMUSG00000035683 10090 + 4:44300876-44364675 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000045607
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000045607 1.077±0.94 0.282±0.06 0.302±0.04 2.592±2.33 0.547±0.20 2.728±0.30 0.060±0.00 0.144±0.06 5.065±5.13 0.444±0.19 0.021±0.01 1.569±1.05 7.674±4.99 1.033±0.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006K5 CIL_0006K5_0002 CGP 4:44126210-44364675
CIL_0006K6 CIL_0006K6_0002 CGP 4:44300876-44710487

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 ISS plasma membrane
GO:0005938 ISS cell cortex
GO:0006915 ISS apoptotic process
GO:0007049 IEA cell cycle
GO:0008283 ISS cell proliferation
GO:0008289 IEA lipid binding
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030097 ISS hemopoiesis
GO:0043065 IDA positive regulation of apoptotic process
GO:0046777 ISS protein autophosphorylation
GO:0061351 IDA neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000298048 MELK-001 protein_coding Homo_sapiens 0 1945
ENST00000480021 MELK-004 processed_transcript Homo_sapiens 0 219
ENST00000487398 MELK-002 processed_transcript Homo_sapiens 0 728
ENST00000489766 MELK-003 processed_transcript Homo_sapiens 0 344
ENST00000495529 MELK-005 processed_transcript Homo_sapiens 0 483
ENST00000536329 MELK-201 protein_coding Homo_sapiens 0 1605
ENST00000536860 MELK-202 protein_coding Homo_sapiens 0 1408
ENST00000536987 MELK-203 protein_coding Homo_sapiens 0 1408
ENST00000541717 MELK-204 protein_coding Homo_sapiens 0 1253
ENST00000543751 MELK-205 protein_coding Homo_sapiens 0 1731
ENST00000545008 MELK-206 protein_coding Homo_sapiens 0 1323

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