C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039621 Prex1 10090 - 2:166566342-166713832 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000036719 Prex1-001 166566342-166713832 protein_coding
  ENSMUST00000099080 Prex1-003 166566960-166638968 protein_coding
  ENSMUST00000109246 Prex1-004 166566966-166582071 protein_coding
  ENSMUST00000127553 Prex1-002 166644382-166713791 retained_intron
  ENSMUST00000136564 Prex1-007 166599678-166603087 retained_intron
  ENSMUST00000136974 Prex1-008 166568317-166572977 processed_transcript
  ENSMUST00000140624 Prex1-005 166644595-166713602 retained_intron
  ENSMUST00000152238 Prex1-006 166633423-166703594 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000036719ENSMUST00000099080ENSMUST00000109246
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000036719 6.904±3.46 11.789±0.84 2.405±0.11 18.435±3.58 24.696±15.82 5.933±1.07 2.111±0.36 4.392±0.63 3.828±2.45 19.212±2.61 1.229±0.27 9.846±2.41 6.408±1.73 1.675±0.35
ENSMUST00000099080 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.727±0.34
ENSMUST00000109246 N/A N/A N/A N/A N/A 3.104±0.41 0.998±0.00 N/A 1.161±0.59 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NU CIL_0008NU_0002 VISTA 2:166052865-166654821
CIL_00025A CIL_00025A_0002 CGP 2:166073089-166713832
CIL_0008GE CIL_0008GE_0002 VISTA 2:166140620-166743127

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005543 IEA phospholipid binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0007186 IGI G-protein coupled receptor signaling pathway
GO:0030217 IGI T cell differentiation
GO:0030426 IEA growth cone
GO:0030593 IGI neutrophil chemotaxis
GO:0030833 IEA regulation of actin filament polymerization
GO:0032855 IGI positive regulation of Rac GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043198 IEA dendritic shaft
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045785 IGI positive regulation of cell adhesion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050773 IEA regulation of dendrite development
GO:0072593 IGI reactive oxygen species metabolic process
GO:1900026 IGI positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075793 prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 protein_coding Danio_rerio
ENSG00000124126 PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 protein_coding Homo_sapiens

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