C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000036719 Prex1-001 ENSMUSG00000039621 10090 - 2:166566342-166713832 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000036719
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000036719 6.904±3.46 11.789±0.84 2.405±0.11 18.435±3.58 24.696±15.82 5.933±1.07 2.111±0.36 4.392±0.63 3.828±2.45 19.212±2.61 1.229±0.27 9.846±2.41 6.408±1.73 1.675±0.35

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NU CIL_0008NU_0002 VISTA 2:166052865-166654821
CIL_00025A CIL_00025A_0002 CGP 2:166073089-166713832
CIL_0008GE CIL_0008GE_0002 VISTA 2:166140620-166743127

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005543 IEA phospholipid binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0007186 IGI G-protein coupled receptor signaling pathway
GO:0030217 IGI T cell differentiation
GO:0030426 IEA growth cone
GO:0030593 IGI neutrophil chemotaxis
GO:0030833 IEA regulation of actin filament polymerization
GO:0032855 IGI positive regulation of Rac GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043198 IEA dendritic shaft
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045785 IGI positive regulation of cell adhesion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050773 IEA regulation of dendrite development
GO:0072593 IGI reactive oxygen species metabolic process
GO:1900026 IGI positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000078022 prex1-201 protein_coding Danio_rerio 9e-26 124
ENSDART00000138289 prex1-001 protein_coding Danio_rerio 9e-26 124
ENST00000371941 PREX1-001 protein_coding Homo_sapiens 0 5494
ENST00000482556 PREX1-002 nonsense_mediated_decay Homo_sapiens 0 2423

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