C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039783 Kmo 10090 + 1:175620381-175662116 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000040250 Kmo-001 175631996-175660853 protein_coding
  ENSMUST00000097458 Kmo-004 175632180-175662116 protein_coding
  ENSMUST00000137174 Kmo-006 175632239-175649265 processed_transcript
  ENSMUST00000140474 Kmo-002 175620381-175659962 nonsense_mediated_decay
  ENSMUST00000142223 Kmo-003 175632001-175654098 retained_intron
  ENSMUST00000150646 Kmo-005 175632026-175637565 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040250ENSMUST00000097458ENSMUST00000140474ENSMUST00000142223ENSMUST00000150646
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040250 0.730±0.28 0.862±0.14 0.023±0.00 2.980±0.35 0.298±0.16 0.160±0.04 24.589±4.08 28.956±22.12 0.945±0.27 0.087±0.12 0.282±0.13 4.520±4.30 0.193±0.13
ENSMUST00000097458 0.205±0.00 0.102±0.00 0.008±0.00 N/A 0.126±0.00 N/A N/A N/A 0.149±0.00 0.025±0.01 0.066±0.02 0.070±0.00 0.088±0.05
ENSMUST00000140474 N/A N/A 0.032±0.00 N/A N/A N/A N/A N/A 0.613±0.00 0.012±0.00 0.253±0.17 0.040±0.00 0.318±0.02
ENSMUST00000142223 N/A N/A 0.005±0.00 N/A N/A 0.142±0.00 N/A N/A N/A N/A 0.259±0.04 N/A 0.070±0.00
ENSMUST00000150646 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.066±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000L5 CIL_0000L5_0003 CGP 1:175059736-175625635
CIL_0000HM CIL_0000HM_0002 CGP 1:175600374-175662116
CIL_0000I7 CIL_0000I7_0002 CGP 1:175620381-175692776

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004502 ISS kynurenine 3-monooxygenase activity
GO:0005739 IDA mitochondrion
GO:0005741 ISS mitochondrial outer membrane
GO:0005743 IDA mitochondrial inner membrane
GO:0009651 IEA response to salt stress
GO:0016021 IEA integral component of membrane
GO:0016174 IEA NAD(P)H oxidase activity
GO:0019441 IEA tryptophan catabolic process to kynurenine
GO:0019674 ISS NAD metabolic process
GO:0019805 IEA quinolinate biosynthetic process
GO:0034354 IEA 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 IEA anthranilate metabolic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0055114 IEA oxidation-reduction process
GO:0070062 IEA extracellular vesicular exosome
GO:0070189 IEA kynurenine metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009160 kmo kynurenine 3-monooxygenase protein_coding Danio_rerio
ENSDARG00000088056 KMO (2 of 2) kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) protein_coding Danio_rerio
ENSG00000117009 KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) protein_coding Homo_sapiens

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