C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040268 Plekha1 10090 + 7:130865756-130913312 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048180 Plekha1-003 130865910-130913302 protein_coding
  ENSMUST00000075181 Plekha1-001 130865898-130912068 protein_coding
  ENSMUST00000120441 Plekha1-002 130865756-130913312 protein_coding
  ENSMUST00000126355 Plekha1-011 130904904-130911163 protein_coding
  ENSMUST00000135359 Plekha1-012 130905304-130910901 retained_intron
  ENSMUST00000136963 Plekha1-009 130900534-130909676 processed_transcript
  ENSMUST00000140153 Plekha1-006 130865887-130878153 retained_intron
  ENSMUST00000146111 Plekha1-010 130902245-130908900 retained_intron
  ENSMUST00000148513 Plekha1-005 130865885-130894741 retained_intron
  ENSMUST00000149029 Plekha1-008 130896991-130905426 retained_intron
  ENSMUST00000151119 Plekha1-004 130865903-130909821 nonsense_mediated_decay
  ENSMUST00000154282 Plekha1-007 130882352-130885520 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000048180ENSMUST00000075181ENSMUST00000120441ENSMUST00000149029ENSMUST00000151119
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000048180 N/A N/A 8.700±2.12 13.627±8.48 3.201±0.00 7.384±5.63 N/A N/A 2.759±3.47 N/A 2.695±0.00 6.892±0.00 6.630±3.64 0.542±0.07
ENSMUST00000075181 N/A N/A N/A 9.109±0.00 5.434±0.00 N/A N/A N/A N/A N/A 1.919±0.00 10.779±0.00 10.451±5.32 2.559±0.00
ENSMUST00000120441 2.195±0.00 1.096±0.00 8.671±0.38 21.589±5.58 3.459±0.84 N/A 4.137±0.07 3.696±0.48 2.022±2.57 6.399±1.57 2.491±1.73 4.569±0.92 6.707±0.57 0.948±0.00
ENSMUST00000149029 N/A N/A N/A 13.654±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 25.916±0.00 N/A
ENSMUST00000151119 N/A N/A N/A 21.893±0.00 N/A N/A N/A N/A N/A N/A N/A 5.101±0.00 N/A 0.822±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WI CIL_0002WI_0002 CGP 7:129591863-133123350
CIL_0001BE CIL_0001BE_0002 CGP 7:130162451-133123350
CIL_0001BB CIL_0001BB_0002 CGP 7:130774069-130913312
CIL_0005TA CIL_0005TA_0002 CGP 7:130865756-130985660

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001553 IGI luteinization
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0007283 IMP spermatogenesis
GO:0008209 IMP androgen metabolic process
GO:0008210 IGI estrogen metabolic process
GO:0008585 IGI female gonad development
GO:0009791 IMP post-embryonic development
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0030165 IEA PDZ domain binding
GO:0031529 IEA ruffle organization
GO:0032587 IEA ruffle membrane
GO:0033327 IMP Leydig cell differentiation
GO:0035264 IMP multicellular organism growth
GO:0043325 IEA phosphatidylinositol-3,4-bisphosphate binding
GO:0045184 IEA establishment of protein localization
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0048705 IMP skeletal system morphogenesis
GO:0050853 IEA B cell receptor signaling pathway
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0060021 IMP palate development
GO:0060325 IMP face morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0070301 IEA cellular response to hydrogen peroxide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030064 plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 protein_coding Danio_rerio
ENSDARG00000094504 PLEKHA1 (2 of 2) pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 protein_coding Danio_rerio
ENSG00000107679 PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 protein_coding Homo_sapiens

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