C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pre B cell leukemia homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052534 Pbx1 10090 - 1:168119364-168432270 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064438 Pbx1-005 168158732-168431504 protein_coding
  ENSMUST00000072863 Pbx1-201 168183573-168432169 protein_coding
  ENSMUST00000097471 Pbx1-009 168158370-168164662 processed_transcript
  ENSMUST00000176309 Pbx1-003 168120969-168405601 protein_coding
  ENSMUST00000176482 Pbx1-006 168208343-168431660 retained_intron
  ENSMUST00000176540 Pbx1-002 168153542-168431897 protein_coding
  ENSMUST00000176790 Pbx1-004 168158330-168431750 protein_coding
  ENSMUST00000176791 Pbx1-007 168424442-168432169 retained_intron
  ENSMUST00000188912 Pbx1-001 168119364-168432270 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000072863ENSMUST00000176540ENSMUST00000176790ENSMUST00000188912
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000072863 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 11.445±0.00 0.733±0.00 N/A
ENSMUST00000176540 21.145±10.61 2.801±0.00 9.431±0.25 15.922±13.90 3.430±1.26 1.501±0.07 5.546±0.00 2.361±0.00 0.676±0.11 4.663±0.00 1.944±0.63 8.715±2.48 1.048±0.48 1.160±0.02
ENSMUST00000176790 16.787±11.77 15.796±1.30 N/A N/A 6.480±1.87 7.748±1.63 6.703±0.29 11.538±2.64 2.001±0.72 14.837±3.28 N/A 31.311±11.91 2.508±1.00 1.849±0.20
ENSMUST00000188912 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.712±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094F CIL_00094F_0002 VISTA 1:167868619-168470073
CIL_0008FU CIL_0008FU_0002 VISTA 1:167968572-168569856
CIL_00089R CIL_00089R_0002 VISTA 1:167994791-168596737
CIL_00096W CIL_00096W_0002 VISTA 1:167999764-168600980
CIL_0009AB CIL_0009AB_0002 VISTA 1:168027071-168628497
CIL_0008NA CIL_0008NA_0002 VISTA 1:168041597-168642833
CIL_0007US CIL_0007US_0002 VISTA 1:168057093-168658535

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001655 IMP urogenital system development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0003677 IDA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006694 IEA steroid biosynthetic process
GO:0007548 IEA sex differentiation
GO:0008134 IEA transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009887 IMP organ morphogenesis
GO:0009952 IMP anterior/posterior pattern specification
GO:0009954 IMP proximal/distal pattern formation
GO:0010971 IMP positive regulation of G2/M transition of mitotic cell cycle
GO:0030278 IMP regulation of ossification
GO:0030325 IMP adrenal gland development
GO:0030326 IGI embryonic limb morphogenesis
GO:0035162 IMP embryonic hemopoiesis
GO:0042127 IMP regulation of cell proliferation
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0048536 IGI spleen development
GO:0048538 IMP thymus development
GO:0048568 IMP embryonic organ development
GO:0048706 IMP embryonic skeletal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089550 pbx1b pre-B-cell leukemia transcription factor 1b protein_coding Danio_rerio
ENSDARG00000089610 pbx1a pre-B-cell leukemia transcription factor 1a protein_coding Danio_rerio
ENSG00000185630 PBX1 pre-B-cell leukemia homeobox 1 protein_coding Homo_sapiens

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