C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pre-B-cell leukemia homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185630 PBX1 9606 + 1:164555584-164899296 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340699 PBX1-007 164559407-164792738 protein_coding
  ENST00000367897 PBX1-002 164559823-164846955 protein_coding
  ENST00000420696 PBX1-001 164559635-164851831 protein_coding
  ENST00000465089 PBX1-005 164812728-164850357 retained_intron
  ENST00000467023 PBX1-008 164555584-164564015 processed_transcript
  ENST00000468104 PBX1-004 164605193-164847071 processed_transcript
  ENST00000474046 PBX1-003 164626036-164682483 processed_transcript
  ENST00000482110 PBX1-009 164630981-164799889 protein_coding
  ENST00000485769 PBX1-006 164559200-164560357 protein_coding
  ENST00000496120 PBX1-016 164590350-164847101 processed_transcript
  ENST00000498497 PBX1-010 164559823-164684965 retained_intron
  ENST00000540236 PBX1-201 164792492-164851821 protein_coding
  ENST00000558796 PBX1-011 164651896-164899296 processed_transcript
  ENST00000558837 PBX1-019 164772912-164807571 protein_coding
  ENST00000559240 PBX1-012 164559823-164848522 protein_coding
  ENST00000559560 PBX1-018 164787643-164799796 protein_coding
  ENST00000559578 PBX1-013 164562805-164799883 protein_coding
  ENST00000560469 PBX1-015 164576784-164847101 processed_transcript
  ENST00000560641 PBX1-017 164626006-164848522 protein_coding
  ENST00000605467 PBX1-014 164560013-164560450 retained_intron
  ENST00000612123 PBX1-202 164792492-164851821 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000420696ENST00000465089ENST00000468104ENST00000496120ENST00000498497ENST00000540236ENST00000558796ENST00000612123
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000420696 N/A 1.886±0.00 1.698±0.00 N/A 2.824±0.00 2.086±0.00 N/A N/A 7.961±7.70 2.582±1.56 N/A 6.503±5.72 1.280±0.40 N/A
ENST00000465089 N/A N/A 1.233±0.00 N/A 1.592±0.00 N/A 0.466±0.00 0.195±0.00 3.435±0.00 1.201±0.00 N/A 1.376±0.00 N/A N/A
ENST00000468104 N/A N/A N/A N/A N/A N/A N/A 1.773±0.00 N/A N/A N/A N/A N/A N/A
ENST00000496120 N/A N/A N/A N/A N/A N/A 3.745±0.00 N/A N/A N/A 5.889±0.00 N/A N/A N/A
ENST00000498497 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.069±0.00 N/A N/A N/A
ENST00000540236 2.330±0.00 N/A N/A 5.025±0.00 4.768±0.00 7.329±0.00 4.936±0.00 4.398±0.00 N/A N/A 7.980±0.00 N/A 1.336±0.00 7.001±4.14
ENST00000558796 2.894±0.00 6.645±0.00 5.335±0.00 3.633±0.00 3.106±0.00 1.437±0.20 1.867±0.00 1.267±0.82 2.733±1.62 1.899±1.55 1.726±0.00 1.917±0.82 N/A 2.041±1.89
ENST00000612123 6.145±0.00 8.032±0.00 N/A 6.900±0.00 5.507±2.63 8.409±0.00 N/A 2.190±0.00 0.530±0.00 1.933±0.00 N/A 11.171±6.55 3.816±0.76 5.164±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007M6 CIL_0007M6_0001 UCNEbase 1:164054328-164712505
CIL_0007US CIL_0007US_0001 VISTA 1:164334904-164936237
CIL_0008NA CIL_0008NA_0001 VISTA 1:164350801-164951927
CIL_0009AB CIL_0009AB_0001 VISTA 1:164368338-164969800
CIL_00096W CIL_00096W_0001 VISTA 1:164399355-165000586
CIL_00089R CIL_00089R_0001 VISTA 1:164403550-165004969
CIL_0008FU CIL_0008FU_0001 VISTA 1:164431022-165032285
CIL_00094F CIL_00094F_0001 VISTA 1:164536270-165137557

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001655 IEA urogenital system development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0003677 IDA:IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006694 IEA steroid biosynthetic process
GO:0007548 IEA sex differentiation
GO:0008134 IPI transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0009952 IEA anterior/posterior pattern specification
GO:0009954 IEA proximal/distal pattern formation
GO:0010971 IEA positive regulation of G2/M transition of mitotic cell cycle
GO:0030278 IEA regulation of ossification
GO:0030325 IEA adrenal gland development
GO:0030326 IEA embryonic limb morphogenesis
GO:0035162 IEA embryonic hemopoiesis
GO:0042127 IEA regulation of cell proliferation
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048536 IEA spleen development
GO:0048538 IEA thymus development
GO:0048568 IEA embryonic organ development
GO:0048706 IEA embryonic skeletal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089550 pbx1b pre-B-cell leukemia transcription factor 1b protein_coding Danio_rerio
ENSDARG00000089610 pbx1a pre-B-cell leukemia transcription factor 1a protein_coding Danio_rerio
ENSMUSG00000052534 Pbx1 pre B cell leukemia homeobox 1 protein_coding Mus_musculus

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