C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000053477 Tcf4 10090 + 18:69344146-69687967 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066717 Tcf4-003 69344146-69684343 protein_coding
  ENSMUST00000078486 Tcf4-201 69345721-69687967 protein_coding
  ENSMUST00000114977 Tcf4-008 69593426-69684526 protein_coding
  ENSMUST00000114978 Tcf4-007 69593417-69683252 protein_coding
  ENSMUST00000114980 Tcf4-004 69346203-69683248 protein_coding
  ENSMUST00000114982 Tcf4-002 69345771-69684526 protein_coding
  ENSMUST00000114985 Tcf4-001 69344510-69687925 protein_coding
  ENSMUST00000125154 Tcf4-009 69521538-69564687 processed_transcript
  ENSMUST00000126946 Tcf4-010 69521793-69633654 processed_transcript
  ENSMUST00000128706 Tcf4-005 69344492-69565506 retained_intron
  ENSMUST00000136019 Tcf4-013 69682380-69683573 retained_intron
  ENSMUST00000136151 Tcf4-011 69563335-69636964 processed_transcript
  ENSMUST00000145918 Tcf4-014 69599536-69651289 processed_transcript
  ENSMUST00000146908 Tcf4-012 69679699-69684528 retained_intron
  ENSMUST00000155695 Tcf4-006 69345771-69487850 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000078486ENSMUST00000114977ENSMUST00000114978ENSMUST00000114980ENSMUST00000114985ENSMUST00000145918ENSMUST00000146908
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000078486 8.606±3.25 2.743±0.40 3.826±0.31 21.168±5.79 5.052±1.53 1.839±0.50 4.881±0.94 2.050±0.99 0.909±0.23 8.540±2.54 1.124±0.52 3.899±2.02 1.829±0.18 0.340±0.00
ENSMUST00000114977 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.427±0.00
ENSMUST00000114978 10.794±1.33 14.242±4.45 N/A 79.526±0.00 18.268±5.01 5.841±0.69 14.278±2.06 5.809±1.00 1.181±0.26 26.353±0.26 N/A 19.390±10.58 12.594±5.91 2.361±1.33
ENSMUST00000114980 N/A 2.356±0.00 N/A 28.390±0.00 N/A 2.413±0.35 N/A 1.472±0.24 0.657±0.21 N/A N/A 6.366±7.17 6.534±3.82 1.858±0.82
ENSMUST00000114985 2.668±0.00 3.474±0.00 1.854±0.89 6.408±3.76 N/A 1.603±0.28 N/A 0.990±0.21 0.584±0.25 3.903±0.00 0.869±0.18 6.063±0.74 0.893±0.30 N/A
ENSMUST00000145918 N/A N/A N/A N/A 13.911±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000146908 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.615±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007L3 CIL_0007L3_0002 UCNEbase 18:68737371-69577988
CIL_0008QS CIL_0008QS_0002 VISTA 18:68795835-69396788
CIL_000821 CIL_000821_0002 VISTA 18:68824560-69425811
CIL_0008DW CIL_0008DW_0002 VISTA 18:69199161-69800797
CIL_00091Y CIL_00091Y_0002 VISTA 18:69262176-69863579
CIL_0008CT CIL_0008CT_0002 VISTA 18:69306431-69910049

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001011 IDA sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001087 IDA TFIIB-class binding transcription factor activity
GO:0001093 IDA TFIIB-class transcription factor binding
GO:0003677 IDA DNA binding
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0006352 IDA DNA-templated transcription, initiation
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006367 IDA transcription initiation from RNA polymerase II promoter
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0065004 IDA protein-DNA complex assembly
GO:0070888 IDA E-box binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087652 tcf4 transcription factor 4 protein_coding Danio_rerio
ENSG00000196628 TCF4 transcription factor 4 protein_coding Homo_sapiens

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