C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: insulin-like growth factor I receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000005671 Igf1r-201 ENSMUSG00000005533 10090 + 7:67952859-68226780 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005671
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005671 1.255±0.41 12.224±2.51 2.107±0.98 2.335±0.51 2.026±0.38 9.792±3.53 0.284±0.36 6.170±2.86 1.022±0.31 12.830±3.94 6.154±3.34 1.299±0.54

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TF CIL_0008TF_0002 VISTA 7:67710091-68313211
CIL_0009CO CIL_0009CO_0002 VISTA 7:67827362-68430866
CIL_0000GM CIL_0000GM_0002 CGP 7:67952859-68264233

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001965 IEA G-protein alpha-subunit binding
GO:0004713 ISS protein tyrosine kinase activity
GO:0005010 ISS insulin-like growth factor-activated receptor activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005520 ISS insulin-like growth factor binding
GO:0005524 IEA ATP binding
GO:0005886 IDA plasma membrane
GO:0005901 IEA caveola
GO:0006468 IDA protein phosphorylation
GO:0006955 IEA immune response
GO:0007409 IEA axonogenesis
GO:0007420 IMP brain development
GO:0008544 IMP epidermis development
GO:0009887 IMP organ morphogenesis
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0016021 IDA integral component of membrane
GO:0030010 IEA establishment of cell polarity
GO:0030238 IMP male sex determination
GO:0030335 IEA positive regulation of cell migration
GO:0030879 IMP mammary gland development
GO:0031017 IMP exocrine pancreas development
GO:0031175 IEA neuron projection development
GO:0031994 IEA insulin-like growth factor I binding
GO:0032467 IEA positive regulation of cytokinesis
GO:0033197 IEA response to vitamin E
GO:0038083 IDA peptidyl-tyrosine autophosphorylation
GO:0042802 IEA identical protein binding
GO:0043005 IEA neuron projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043235 ISO receptor complex
GO:0043409 IMP negative regulation of MAPK cascade
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043548 ISS phosphatidylinositol 3-kinase binding
GO:0043559 IEA insulin binding
GO:0043560 ISS insulin receptor substrate binding
GO:0045740 IEA positive regulation of DNA replication
GO:0045840 IMP positive regulation of mitosis
GO:0046328 IEA regulation of JNK cascade
GO:0046777 ISS protein autophosphorylation
GO:0048009 IC:ISS insulin-like growth factor receptor signaling pathway
GO:0048015 IEA phosphatidylinositol-mediated signaling
GO:0051054 IEA positive regulation of DNA metabolic process
GO:0051262 ISS protein tetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051389 IEA inactivation of MAPKK activity
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051898 IMP negative regulation of protein kinase B signaling
GO:0060740 IMP prostate gland epithelium morphogenesis
GO:0090031 IEA positive regulation of steroid hormone biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000010189 igf1ra-001 protein_coding Danio_rerio 0 780
ENSDART00000046542 igf1rb-001 protein_coding Danio_rerio 0 723
ENST00000268035 IGF1R-001 protein_coding Homo_sapiens 0 5470
ENST00000557938 IGF1R-014 processed_transcript Homo_sapiens 0 536
ENST00000558355 IGF1R-017 protein_coding Homo_sapiens 0 697
ENST00000558751 IGF1R-005 processed_transcript Homo_sapiens 0 311
ENST00000558762 IGF1R-002 protein_coding Homo_sapiens 0 5467
ENST00000558898 IGF1R-011 protein_coding Homo_sapiens 0 990
ENST00000558947 IGF1R-009 processed_transcript Homo_sapiens 8e-39 163
ENST00000559582 IGF1R-008 processed_transcript Homo_sapiens 0 490
ENST00000559925 IGF1R-003 retained_intron Homo_sapiens 0 2750
ENST00000560144 IGF1R-016 nonsense_mediated_decay Homo_sapiens 0 503
ENST00000560972 IGF1R-004 protein_coding Homo_sapiens 0 313
ENST00000561049 IGF1R-007 retained_intron Homo_sapiens 0 654

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