C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000022176 Hmgcr-001 ENSMUSG00000021670 10090 - 13:96648967-96670936 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022176
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022176 4.164±1.56 11.149±4.83 7.222±1.21 29.485±8.59 3.673±0.24 14.908±1.67 1.538±0.09 13.920±3.69 25.583±12.14 9.216±0.50 0.821±0.11 14.299±6.31 17.057±10.34 18.066±5.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XB CIL_0002XB_0003 CGP 13:96542618-96670936

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004420 IDA hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 IEA protein binding
GO:0005778 IEA peroxisomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0006695 IDA cholesterol biosynthetic process
GO:0006743 IEA ubiquinone metabolic process
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008284 IEA positive regulation of cell proliferation
GO:0008542 IGI visual learning
GO:0010664 IEA negative regulation of striated muscle cell apoptotic process
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0015936 IEA coenzyme A metabolic process
GO:0016021 IEA integral component of membrane
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0042282 IEA hydroxymethylglutaryl-CoA reductase activity
GO:0042803 IEA protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043407 IGI negative regulation of MAP kinase activity
GO:0045445 IEA myoblast differentiation
GO:0045471 IEA response to ethanol
GO:0045908 IEA negative regulation of vasodilation
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051262 IEA protein tetramerization
GO:0055114 IEA oxidation-reduction process
GO:0061045 IEA negative regulation of wound healing
GO:0061179 IEA negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070402 IEA NADPH binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000287936 HMGCR-001 protein_coding Homo_sapiens 0 3123
ENST00000343975 HMGCR-004 protein_coding Homo_sapiens 0 1681
ENST00000504466 HMGCR-007 retained_intron Homo_sapiens 0 671
ENST00000508070 HMGCR-011 retained_intron Homo_sapiens 0 335
ENST00000509085 HMGCR-005 protein_coding Homo_sapiens 0 350
ENST00000511206 HMGCR-002 protein_coding Homo_sapiens 0 3103
ENST00000511986 HMGCR-006 protein_coding Homo_sapiens 0 342
ENST00000512053 HMGCR-014 retained_intron Homo_sapiens 0 399
ENST00000514315 HMGCR-013 retained_intron Homo_sapiens 0 508
ENST00000515776 HMGCR-012 retained_intron Homo_sapiens 0 346

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