C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: amyotrophic lateral sclerosis 2 (juvenile)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000027178 Als2-001 ENSMUSG00000026024 10090 - 1:59162926-59237231 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027178
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027178 4.366±0.61 1.672±0.32 3.908±0.14 8.591±1.01 3.081±0.49 1.151±0.43 1.720±0.14 6.271±0.68 9.761±4.92 3.430±0.13 4.668±0.30 3.301±1.29 10.736±3.12 3.370±0.64

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089O CIL_00089O_0002 VISTA 1:58652904-59256413
CIL_0009CR CIL_0009CR_0002 VISTA 1:59040862-59642046
CIL_00020O CIL_00020O_0002 CGP 1:59100590-59163389
CIL_0000JK CIL_0000JK_0003 CGP 1:59120935-59237231
CIL_0000JL CIL_0000JL_0003 CGP 1:59162926-59352993

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001662 IMP behavioral fear response
GO:0001726 IDA ruffle
GO:0001881 IMP receptor recycling
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005769 ISS early endosome
GO:0005813 IDA centrosome
GO:0005829 ISS cytosol
GO:0006979 IMP response to oxidative stress
GO:0007528 IMP neuromuscular junction development
GO:0007626 IMP locomotory behavior
GO:0008104 IMP protein localization
GO:0014069 IDA postsynaptic density
GO:0016050 IDA vesicle organization
GO:0016197 IMP endosomal transport
GO:0017112 ISS Rab guanyl-nucleotide exchange factor activity
GO:0017137 ISS Rab GTPase binding
GO:0030027 IDA lamellipodium
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030676 ISS Rac guanyl-nucleotide exchange factor activity
GO:0031982 ISS vesicle
GO:0032313 IDA regulation of Rab GTPase activity
GO:0032851 ISS positive regulation of Rab GTPase activity
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0035249 IMP synaptic transmission, glutamatergic
GO:0042803 ISS protein homodimerization activity
GO:0043197 IDA dendritic spine
GO:0043234 ISS protein complex
GO:0043539 ISS protein serine/threonine kinase activator activity
GO:0045860 ISS positive regulation of protein kinase activity
GO:0048812 ISS neuron projection morphogenesis
GO:0051036 ISS regulation of endosome size
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264276 ALS2-001 protein_coding Homo_sapiens 0 5729
ENST00000409632 ALS2-009 protein_coding Homo_sapiens 0 575
ENST00000410052 ALS2-006 protein_coding Homo_sapiens 0 472
ENST00000439495 ALS2-005 nonsense_mediated_decay Homo_sapiens 0 2100
ENST00000467448 ALS2-002 protein_coding Homo_sapiens 0 1046
ENST00000482789 ALS2-003 retained_intron Homo_sapiens 0 2392
ENST00000482891 ALS2-004 retained_intron Homo_sapiens 0 4178
ENST00000483703 ALS2-010 processed_transcript Homo_sapiens 0 444
ENST00000489440 ALS2-012 processed_transcript Homo_sapiens 0 876
ENST00000494017 ALS2-011 processed_transcript Homo_sapiens 0 584
ENST00000496244 ALS2-007 processed_transcript Homo_sapiens 0 462

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