C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000027559 Tnfrsf11a-001 ENSMUSG00000026321 10090 + 1:105780718-105847981 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027559
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027559 1.748±0.48 1.546±0.56 5.335±1.83 0.288±0.10 2.653±0.99 27.818±7.64 0.481±0.08 1.175±0.21 0.264±0.11 2.029±0.17 0.094±0.05 1.946±0.91 0.285±0.25 0.125±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00071U CIL_00071U_0002 CGP 1:105663861-105847981
CIL_00076G CIL_00076G_0002 CGP 1:105780718-106034074

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001503 IMP ossification
GO:0002250 IEA adaptive immune response
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005031 IMP tumor necrosis factor-activated receptor activity
GO:0005515 IPI protein binding
GO:0007275 IMP multicellular organismal development
GO:0009314 IEA response to radiation
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0019955 IEA cytokine binding
GO:0030316 IEA osteoclast differentiation
GO:0032496 IMP response to lipopolysaccharide
GO:0033209 IMP tumor necrosis factor-mediated signaling pathway
GO:0034097 IEA response to cytokine
GO:0034612 IMP response to tumor necrosis factor
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0046872 IEA metal ion binding
GO:0048535 IMP lymph node development
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0060086 IMP circadian temperature homeostasis
GO:0060749 IMP mammary gland alveolus development
GO:0070555 IMP response to interleukin-1
GO:0071812 IMP positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IEA TNFSF11-mediated signaling pathway
GO:0071848 IEA positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000269485 TNFRSF11A-002 protein_coding Homo_sapiens 0 590
ENST00000586569 TNFRSF11A-001 protein_coding Homo_sapiens 0 1105
ENST00000616710 TNFRSF11A-201 protein_coding Homo_sapiens 0 699
ENST00000617039 TNFRSF11A-202 protein_coding Homo_sapiens 0 652

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