C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: rho/rac guanine nucleotide exchange factor (GEF) 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029694 Arhgef2-001 ENSMUSG00000028059 10090 + 3:88621106-88648052 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000029694
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000029694 9.651±2.92 2.872±1.06 7.521±0.38 17.016±2.52 6.356±1.94 4.642±0.86 4.443±1.02 8.443±0.33 2.345±1.78 17.200±0.65 1.607±0.65 7.007±2.42 9.698±4.79

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P5 CIL_0008P5_0002 VISTA 3:88218217-88823366
CIL_000898 CIL_000898_0002 VISTA 3:88224783-88827970

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000132 IMP establishment of mitotic spindle orientation
GO:0000902 IDA:ISS cell morphogenesis
GO:0005089 IDA:ISS Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005856 ISS cytoskeleton
GO:0005874 ISS microtubule
GO:0005923 IEA tight junction
GO:0005925 IEA focal adhesion
GO:0007015 IPI:ISS actin filament organization
GO:0007026 ISS negative regulation of microtubule depolymerization
GO:0007067 IEA mitotic nuclear division
GO:0008017 IDA:ISS microtubule binding
GO:0017048 ISS Rho GTPase binding
GO:0030676 ISS Rac guanyl-nucleotide exchange factor activity
GO:0031410 IEA cytoplasmic vesicle
GO:0031982 ISS vesicle
GO:0032321 IDA:ISS positive regulation of Rho GTPase activity
GO:0032587 ISS ruffle membrane
GO:0032755 ISS positive regulation of interleukin-6 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0035023 IDA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0043025 IDA neuronal cell body
GO:0043198 IDA dendritic shaft
GO:0043234 ISS protein complex
GO:0045087 IEA innate immune response
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048365 ISS Rac GTPase binding
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 IMP negative regulation of neurogenesis
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0071225 ISS cellular response to muramyl dipeptide

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000313667 ARHGEF2-002 protein_coding Homo_sapiens 0 2976
ENST00000313695 ARHGEF2-003 protein_coding Homo_sapiens 0 2944
ENST00000361247 ARHGEF2-001 protein_coding Homo_sapiens 0 3037
ENST00000368315 ARHGEF2-201 protein_coding Homo_sapiens 0 1020
ENST00000462460 ARHGEF2-004 protein_coding Homo_sapiens 0 2961
ENST00000465079 ARHGEF2-011 retained_intron Homo_sapiens 0 213
ENST00000470874 ARHGEF2-009 nonsense_mediated_decay Homo_sapiens 0 398
ENST00000471589 ARHGEF2-010 protein_coding Homo_sapiens 0 902
ENST00000476273 ARHGEF2-008 processed_transcript Homo_sapiens 0 464
ENST00000487755 ARHGEF2-006 retained_intron Homo_sapiens 0 217
ENST00000495070 ARHGEF2-005 protein_coding Homo_sapiens 8e-17 92
ENST00000497907 ARHGEF2-012 protein_coding Homo_sapiens 0 848
ENST00000608543 ARHGEF2-013 retained_intron Homo_sapiens 0 219
ENST00000609707 ARHGEF2-018 protein_coding Homo_sapiens 0 654

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