C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ISL1 transcription factor, LIM/homeodomain
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000036060 Isl1-001 ENSMUSG00000042258 10090 - 13:116298281-116309689 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000036060
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000036060 0.095±0.05 2.031±0.32 1.455±0.08 7.201±5.83 0.485±0.29 1.107±0.19 0.080±0.05 0.097±0.05 0.063±0.07 0.336±0.24 0.084±0.04 0.085±0.03 0.073±0.03 0.056±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KS CIL_0008KS_0002 VISTA 13:115786721-116388319
CIL_000918 CIL_000918_0002 VISTA 13:115978490-116580024
CIL_0008U0 CIL_0008U0_0002 VISTA 13:116197241-116798253
CIL_000931 CIL_000931_0002 VISTA 13:116214002-116815994
CIL_0009BI CIL_0009BI_0002 VISTA 13:116275049-116876418

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001158 IEA enhancer sequence-specific DNA binding
GO:0001755 IGI neural crest cell migration
GO:0003007 IGI heart morphogenesis
GO:0003139 IEA secondary heart field specification
GO:0003148 IGI outflow tract septum morphogenesis
GO:0003151 IGI outflow tract morphogenesis
GO:0003203 IGI endocardial cushion morphogenesis
GO:0003215 IGI cardiac right ventricle morphogenesis
GO:0003266 IMP regulation of secondary heart field cardioblast proliferation
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007507 IMP heart development
GO:0008270 IEA zinc ion binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0010468 IMP regulation of gene expression
GO:0010575 IDA positive regulation vascular endothelial growth factor production
GO:0016922 IEA ligand-dependent nuclear receptor binding
GO:0021520 IGI spinal cord motor neuron cell fate specification
GO:0021522 IMP spinal cord motor neuron differentiation
GO:0021524 IGI visceral motor neuron differentiation
GO:0021559 IMP trigeminal nerve development
GO:0021983 IMP pituitary gland development
GO:0030182 IMP neuron differentiation
GO:0030331 IEA estrogen receptor binding
GO:0031016 IMP pancreas development
GO:0031103 IEA axon regeneration
GO:0031290 IMP retinal ganglion cell axon guidance
GO:0032024 IEA positive regulation of insulin secretion
GO:0032725 IDA positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 IDA positive regulation of interferon-gamma production
GO:0032730 IDA positive regulation of interleukin-1 alpha production
GO:0032731 IDA positive regulation of interleukin-1 beta production
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0033147 IEA negative regulation of intracellular estrogen receptor signaling pathway
GO:0042517 IDA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388 IDA positive regulation of DNA binding
GO:0043425 IEA bHLH transcription factor binding
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0048663 IGI neuron fate commitment
GO:0048665 IMP neuron fate specification
GO:0048762 IMP mesenchymal cell differentiation
GO:0048880 IMP sensory system development
GO:0048935 IGI peripheral nervous system neuron development
GO:0048936 IMP peripheral nervous system neuron axonogenesis
GO:0050728 IMP negative regulation of inflammatory response
GO:0055010 IGI ventricular cardiac muscle tissue morphogenesis
GO:0060037 IGI pharyngeal system development
GO:0060379 IMP cardiac muscle cell myoblast differentiation
GO:0060384 IMP innervation
GO:0060413 IGI atrial septum morphogenesis
GO:0060913 IMP cardiac cell fate determination
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:0071657 IDA positive regulation of granulocyte colony-stimulating factor production
GO:0090074 IEA negative regulation of protein homodimerization activity
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:1901258 IDA positive regulation of macrophage colony-stimulating factor production

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000010896 isl1-001 protein_coding Danio_rerio 0 841
ENST00000230658 ISL1-001 protein_coding Homo_sapiens 0 2355
ENST00000505475 ISL1-006 processed_transcript Homo_sapiens 0 1105
ENST00000511384 ISL1-003 protein_coding Homo_sapiens 0 1120

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