C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: bone morphogenetic protein 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000074077 Bmp4-001 ENSMUSG00000021835 10090 - 14:46383520-46390669 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000074077
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000074077 3.015±2.04 2.309±0.67 13.396±0.51 0.433±0.36 1.023±0.23 19.281±2.23 1.750±0.42 6.720±2.42 0.511±0.21 18.108±4.00 0.489±0.18 2.581±0.96 1.303±0.63 0.193±0.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PK CIL_0008PK_0002 VISTA 14:45923997-46524959
CIL_0008PV CIL_0008PV_0002 VISTA 14:45947450-46549128
CIL_0008HY CIL_0008HY_0002 VISTA 14:46086734-46687665
CIL_0008KQ CIL_0008KQ_0002 VISTA 14:46305651-46906520
CIL_00090Z CIL_00090Z_0002 VISTA 14:46310670-46911777
CIL_0005GF CIL_0005GF_0002 CGP 14:46383520-46771525

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISO negative regulation of transcription from RNA polymerase II promoter
GO:0000186 ISS activation of MAPKK activity
GO:0001501 IDA skeletal system development
GO:0001525 IMP angiogenesis
GO:0001568 IDA blood vessel development
GO:0001649 ISS osteoblast differentiation
GO:0001656 IDA metanephros development
GO:0001657 IDA ureteric bud development
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001707 IDA mesoderm formation
GO:0001759 IMP organ induction
GO:0001822 ISS kidney development
GO:0001823 ISS mesonephros development
GO:0001843 IDA neural tube closure
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0001936 TAS regulation of endothelial cell proliferation
GO:0001938 ISS positive regulation of endothelial cell proliferation
GO:0001944 IMP vasculature development
GO:0001958 IMP endochondral ossification
GO:0002043 ISS blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 IMP chondrocyte differentiation
GO:0002244 ISS hematopoietic progenitor cell differentiation
GO:0002320 ISS lymphoid progenitor cell differentiation
GO:0003014 IMP renal system process
GO:0003130 ISS BMP signaling pathway involved in heart induction
GO:0003139 ISS secondary heart field specification
GO:0003323 ISS type B pancreatic cell development
GO:0003337 ISS mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 IEA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0007182 ISS common-partner SMAD protein phosphorylation
GO:0007224 IEA smoothened signaling pathway
GO:0007281 IMP germ cell development
GO:0007500 IMP mesodermal cell fate determination
GO:0007507 IMP heart development
GO:0008083 IEA growth factor activity
GO:0008201 IDA heparin binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0009791 ISO post-embryonic development
GO:0009888 IGI tissue development
GO:0009948 IGI anterior/posterior axis specification
GO:0010159 IMP specification of organ position
GO:0010453 ISS regulation of cell fate commitment
GO:0010468 IDA regulation of gene expression
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010862 ISS positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 ISO positive regulation of cell death
GO:0021537 ISO telencephalon development
GO:0021904 IDA dorsal/ventral neural tube patterning
GO:0021978 IGI telencephalon regionalization
GO:0021983 IMP pituitary gland development
GO:0030218 IDA erythrocyte differentiation
GO:0030224 IEA monocyte differentiation
GO:0030225 IEA macrophage differentiation
GO:0030324 IMP lung development
GO:0030326 IGI embryonic limb morphogenesis
GO:0030501 ISS positive regulation of bone mineralization
GO:0030509 ISS BMP signaling pathway
GO:0030513 IDA positive regulation of BMP signaling pathway
GO:0030900 IGI forebrain development
GO:0030949 TAS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032092 ISO positive regulation of protein binding
GO:0032331 IDA negative regulation of chondrocyte differentiation
GO:0032967 ISS positive regulation of collagen biosynthetic process
GO:0033085 IEA negative regulation of T cell differentiation in thymus
GO:0033088 ISS negative regulation of immature T cell proliferation in thymus
GO:0034504 ISS protein localization to nucleus
GO:0035116 IGI embryonic hindlimb morphogenesis
GO:0035990 IMP tendon cell differentiation
GO:0035993 IMP deltoid tuberosity development
GO:0042056 ISS chemoattractant activity
GO:0042306 ISO regulation of protein import into nucleus
GO:0042326 ISS negative regulation of phosphorylation
GO:0042475 IDA odontogenesis of dentin-containing tooth
GO:0042476 ISS odontogenesis
GO:0042487 IGI regulation of odontogenesis of dentin-containing tooth
GO:0042733 IGI embryonic digit morphogenesis
GO:0043010 IGI camera-type eye development
GO:0043065 ISS positive regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043401 ISS steroid hormone mediated signaling pathway
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0045165 IDA cell fate commitment
GO:0045595 IGI regulation of cell differentiation
GO:0045597 IDA positive regulation of cell differentiation
GO:0045603 IDA positive regulation of endothelial cell differentiation
GO:0045606 ISS positive regulation of epidermal cell differentiation
GO:0045662 IEA negative regulation of myoblast differentiation
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045669 ISS positive regulation of osteoblast differentiation
GO:0045778 ISO positive regulation of ossification
GO:0045786 ISS negative regulation of cell cycle
GO:0045839 ISS negative regulation of mitosis
GO:0045843 IEA negative regulation of striated muscle tissue development
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0048286 ISO lung alveolus development
GO:0048333 IDA mesodermal cell differentiation
GO:0048392 ISS intermediate mesodermal cell differentiation
GO:0048593 IMP camera-type eye morphogenesis
GO:0048598 IMP embryonic morphogenesis
GO:0048646 IGI anatomical structure formation involved in morphogenesis
GO:0048660 IDA regulation of smooth muscle cell proliferation
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0048663 IDA neuron fate commitment
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0048706 IMP embryonic skeletal system development
GO:0048745 IMP smooth muscle tissue development
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050918 ISS positive chemotaxis
GO:0051145 IDA smooth muscle cell differentiation
GO:0051150 IDA regulation of smooth muscle cell differentiation
GO:0055007 NAS cardiac muscle cell differentiation
GO:0055020 ISS positive regulation of cardiac muscle fiber development
GO:0060113 IGI inner ear receptor cell differentiation
GO:0060197 IEP cloacal septation
GO:0060235 IMP lens induction in camera-type eye
GO:0060272 IGI embryonic skeletal joint morphogenesis
GO:0060348 IDA bone development
GO:0060363 IDA cranial suture morphogenesis
GO:0060391 ISS positive regulation of SMAD protein import into nucleus
GO:0060393 ISS regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 ISS SMAD protein signal transduction
GO:0060425 ISO lung morphogenesis
GO:0060429 IDA epithelium development
GO:0060433 ISO bronchus development
GO:0060438 ISO trachea development
GO:0060440 IMP trachea formation
GO:0060441 ISO epithelial tube branching involved in lung morphogenesis
GO:0060442 IMP branching involved in prostate gland morphogenesis
GO:0060449 IDA bud elongation involved in lung branching
GO:0060502 ISO epithelial cell proliferation involved in lung morphogenesis
GO:0060503 ISO bud dilation involved in lung branching
GO:0060512 IMP prostate gland morphogenesis
GO:0060548 ISS negative regulation of cell death
GO:0060592 IMP mammary gland formation
GO:0060684 IDA epithelial-mesenchymal cell signaling
GO:0060686 IMP negative regulation of prostatic bud formation
GO:0060687 IMP regulation of branching involved in prostate gland morphogenesis
GO:0060688 IMP regulation of morphogenesis of a branching structure
GO:0061035 IDA regulation of cartilage development
GO:0061036 ISO positive regulation of cartilage development
GO:0061047 IMP positive regulation of branching involved in lung morphogenesis
GO:0061149 IDA BMP signaling pathway involved in ureter morphogenesis
GO:0061151 IMP BMP signaling pathway involved in renal system segmentation
GO:0061155 ISS pulmonary artery endothelial tube morphogenesis
GO:0070244 ISS negative regulation of thymocyte apoptotic process
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070700 ISS BMP receptor binding
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071893 ISS BMP signaling pathway involved in nephric duct formation
GO:0072001 IGI renal system development
GO:0072015 IEP glomerular visceral epithelial cell development
GO:0072097 ISS negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 ISS specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 IMP glomerular capillary formation
GO:0072125 ISS negative regulation of glomerular mesangial cell proliferation
GO:0072138 IEP mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 IMP mesenchymal cell differentiation involved in kidney development
GO:0072192 IMP ureter epithelial cell differentiation
GO:0072193 IMP ureter smooth muscle cell differentiation
GO:0072198 IEP mesenchymal cell proliferation involved in ureter development
GO:0072200 ISS negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 IMP metanephric collecting duct development
GO:0090184 ISS positive regulation of kidney development
GO:0090191 ISS negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 ISS negative regulation of glomerulus development
GO:2000005 ISS negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 ISS negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105 ISS positive regulation of DNA-dependent DNA replication
GO:2000137 ISS negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 IMP mesenchymal cell differentiation involved in renal system development

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000245451 BMP4-001 protein_coding Homo_sapiens 0 2292
ENST00000417573 BMP4-201 protein_coding Homo_sapiens 0 2102
ENST00000558961 BMP4-007 protein_coding Homo_sapiens 0 414
ENST00000558984 BMP4-003 protein_coding Homo_sapiens 0 2098
ENST00000559087 BMP4-002 protein_coding Homo_sapiens 0 2098
ENST00000559501 BMP4-006 protein_coding Homo_sapiens 0 1343
ENST00000559642 BMP4-004 protein_coding Homo_sapiens 0 715

Loading