C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: enhancer of zeste homolog 2 (Drosophila)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000081721 Ezh2-001 ENSMUSG00000029687 10090 - 6:47530274-47595030 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000081721
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000081721 1.582±0.67 0.357±0.13 4.223±0.75 23.338±5.08 1.406±0.24 0.817±0.21 0.548±0.24 0.871±0.23 11.582±10.91 1.111±0.35 0.767±0.16 2.080±2.03 10.314±6.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XU CIL_0004XU_0002 CGP 6:47453398-47595341
CIL_0004XT CIL_0004XT_0002 CGP 6:47530274-47813512

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0001047 IMP core promoter binding
GO:0001932 IMP regulation of protein phosphorylation
GO:0003682 IDA chromatin binding
GO:0003723 IPI RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006306 IMP DNA methylation
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0010468 IMP regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0014013 IMP regulation of gliogenesis
GO:0014834 IMP skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016571 IDA histone methylation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0021695 IMP cerebellar cortex development
GO:0031490 IEA chromatin DNA binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0034244 IMP negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 IDA ESC/E(Z) complex
GO:0042054 IDA histone methyltransferase activity
GO:0042127 IMP regulation of cell proliferation
GO:0042752 IMP regulation of circadian rhythm
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043565 IDA sequence-specific DNA binding
GO:0045120 IDA pronucleus
GO:0045605 IMP negative regulation of epidermal cell differentiation
GO:0045814 ISS negative regulation of gene expression, epigenetic
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0048387 ISS negative regulation of retinoic acid receptor signaling pathway
GO:0050767 IMP regulation of neurogenesis
GO:0051154 IDA negative regulation of striated muscle cell differentiation
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0070314 IMP G1 to G0 transition
GO:0070734 IMP histone H3-K27 methylation
GO:0071168 IMP protein localization to chromatin
GO:0071902 ISS positive regulation of protein serine/threonine kinase activity
GO:2000134 IMP negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000320356 EZH2-004 protein_coding Homo_sapiens 0 3663
ENST00000350995 EZH2-010 protein_coding Homo_sapiens 0 3070
ENST00000431167 EZH2P1-001 processed_pseudogene Homo_sapiens 0 394
ENST00000460911 EZH2-008 protein_coding Homo_sapiens 0 3681
ENST00000469631 EZH2-009 retained_intron Homo_sapiens 0 261
ENST00000476773 EZH2-007 protein_coding Homo_sapiens 0 1989
ENST00000478654 EZH2-006 protein_coding Homo_sapiens 0 1989
ENST00000483012 EZH2-005 nonsense_mediated_decay Homo_sapiens 0 981
ENST00000483967 EZH2-001 protein_coding Homo_sapiens 0 3356
ENST00000492143 EZH2-003 nonsense_mediated_decay Homo_sapiens 0 1635
ENST00000498186 EZH2-002 retained_intron Homo_sapiens 0 1840

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