C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: toll-like receptor 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000107365 Tlr4-004 ENSMUSG00000039005 10090 + 4:66827613-66930284 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLiverOvaryENSMUST00000107365
Transcript ID Heart Liver Ovary
ENSMUST00000107365 0.390±0.08 0.072±0.00 0.492±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004FM CIL_0004FM_0002 CGP 4:65604986-66930284
CIL_0007YF CIL_0007YF_0002 VISTA 4:66594392-67195290
CIL_0004FN CIL_0004FN_0002 CGP 4:66827584-68954397

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002218 IMP activation of innate immune response
GO:0002322 IMP B cell proliferation involved in immune response
GO:0002537 IMP nitric oxide production involved in inflammatory response
GO:0002755 IEA MyD88-dependent toll-like receptor signaling pathway
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0007252 IMP I-kappaB phosphorylation
GO:0009617 IMP response to bacterium
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032496 IMP response to lipopolysaccharide
GO:0032609 IGI interferon-gamma production
GO:0032733 IDA positive regulation of interleukin-10 production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0032874 IDA positive regulation of stress-activated MAPK cascade
GO:0034142 IEA toll-like receptor 4 signaling pathway
GO:0042116 IEA macrophage activation
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 IEA innate immune response
GO:0045348 IMP positive regulation of MHC class II biosynthetic process
GO:0045359 IMP positive regulation of interferon-beta biosynthetic process
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0046330 IDA positive regulation of JNK cascade
GO:0046696 IEA lipopolysaccharide receptor complex
GO:0050671 IMP positive regulation of lymphocyte proliferation
GO:0050707 IEA regulation of cytokine secretion
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0060907 IMP positive regulation of macrophage cytokine production
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070430 IDA positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 IDA positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071223 IMP cellular response to lipoteichoic acid

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000608958 SETD7-009 protein_coding Homo_sapiens 0.0003 53

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