C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-like receptor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039005 Tlr4 10090 + 4:66827584-66930284 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048096 Tlr4-001 66827584-66842800 protein_coding
  ENSMUST00000107365 Tlr4-004 66827613-66930284 protein_coding
  ENSMUST00000143580 Tlr4-002 66827619-66839429 processed_transcript
  ENSMUST00000147008 Tlr4-003 66828202-66839618 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000048096ENSMUST00000107365ENSMUST00000143580ENSMUST00000147008
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000048096 3.179±0.35 0.402±0.15 1.393±0.05 0.097±0.00 2.298±0.31 1.571±0.34 1.013±0.15 0.756±0.18 0.313±0.15 2.732±0.85 0.240±0.09 0.999±0.38 0.293±0.16 0.058±0.03
ENSMUST00000107365 N/A N/A N/A N/A N/A N/A 0.390±0.08 N/A 0.072±0.00 N/A N/A 0.492±0.10 N/A N/A
ENSMUST00000143580 N/A 0.770±0.14 N/A N/A N/A 1.042±0.00 N/A 1.044±0.00 0.392±0.19 N/A N/A 1.294±0.36 N/A 0.158±0.07
ENSMUST00000147008 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.679±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004FM CIL_0004FM_0002 CGP 4:65604986-66930284
CIL_0007YF CIL_0007YF_0002 VISTA 4:66594392-67195290
CIL_0004FN CIL_0004FN_0002 CGP 4:66827584-68954397

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0001875 ISS lipopolysaccharide receptor activity
GO:0002218 IMP activation of innate immune response
GO:0002322 IMP B cell proliferation involved in immune response
GO:0002537 IMP nitric oxide production involved in inflammatory response
GO:0002755 IEA MyD88-dependent toll-like receptor signaling pathway
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0007250 NAS activation of NF-kappaB-inducing kinase activity
GO:0007252 IMP I-kappaB phosphorylation
GO:0009617 IMP response to bacterium
GO:0009897 IEA external side of plasma membrane
GO:0010572 IMP positive regulation of platelet activation
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032496 IMP response to lipopolysaccharide
GO:0032497 TAS detection of lipopolysaccharide
GO:0032609 IGI interferon-gamma production
GO:0032689 IMP negative regulation of interferon-gamma production
GO:0032700 IMP negative regulation of interleukin-17 production
GO:0032707 IMP negative regulation of interleukin-23 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0032722 IDA positive regulation of chemokine production
GO:0032727 IDA positive regulation of interferon-alpha production
GO:0032728 IDA positive regulation of interferon-beta production
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032732 IDA positive regulation of interleukin-1 production
GO:0032733 IDA positive regulation of interleukin-10 production
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0032874 IDA positive regulation of stress-activated MAPK cascade
GO:0034142 IEA toll-like receptor 4 signaling pathway
GO:0042116 ISS macrophage activation
GO:0042346 IEA positive regulation of NF-kappaB import into nucleus
GO:0042535 IEA positive regulation of tumor necrosis factor biosynthetic process
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045348 IMP positive regulation of MHC class II biosynthetic process
GO:0045359 IMP positive regulation of interferon-beta biosynthetic process
GO:0045362 NAS positive regulation of interleukin-1 biosynthetic process
GO:0045368 NAS positive regulation of interleukin-13 biosynthetic process
GO:0045410 NAS positive regulation of interleukin-6 biosynthetic process
GO:0045416 IEA positive regulation of interleukin-8 biosynthetic process
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045576 NAS mast cell activation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046696 ISS lipopolysaccharide receptor complex
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050671 IMP positive regulation of lymphocyte proliferation
GO:0050707 IEA regulation of cytokine secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051770 IDA positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 IMP intestinal epithelial structure maintenance
GO:0060907 IMP positive regulation of macrophage cytokine production
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070430 IDA positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 IDA positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071223 IMP cellular response to lipoteichoic acid
GO:0071260 IEA cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019742 tlr4ba toll-like receptor 4b, duplicate a protein_coding Danio_rerio
ENSDARG00000022048 tlr4bb toll-like receptor 4b, duplicate b protein_coding Danio_rerio
ENSDARG00000075671 tlr4al toll-like receptor 4a, like protein_coding Danio_rerio
ENSG00000136869 TLR4 toll-like receptor 4 protein_coding Homo_sapiens

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