C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: non-catalytic region of tyrosine kinase adaptor protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000116522 Nck1-001 ENSMUSG00000032475 10090 - 9:100492293-100546134 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000116522
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000116522 1.223±0.21 1.092±0.17 1.195±0.51 1.364±0.83 1.135±0.32 1.870±0.37 0.920±0.16 1.290±0.36 1.483±0.48 3.267±0.71 0.654±0.07 2.040±0.89 2.661±0.01 1.713±0.58

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00092I CIL_00092I_0002 VISTA 9:99894020-100495329
CIL_0009A5 CIL_0009A5_0002 VISTA 9:99910151-100511937
CIL_0009A4 CIL_0009A4_0002 VISTA 9:99971528-100572973
CIL_0001BW CIL_0001BW_0003 CGP 9:100492293-100571090

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004860 ISS protein kinase inhibitor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005783 IEA endoplasmic reticulum
GO:0005911 IDA cell-cell junction
GO:0006417 IEA regulation of translation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006930 IGI substrate-dependent cell migration, cell extension
GO:0007015 IMP actin filament organization
GO:0012506 IDA vesicle membrane
GO:0016477 IMP cell migration
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0030971 IEA receptor tyrosine kinase binding
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042110 IEA T cell activation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051707 IMP response to other organism
GO:0060548 ISS negative regulation of cell death

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000132648 nck1b-001 protein_coding Danio_rerio 0 294
ENSDART00000109339 nck1b-201 protein_coding Danio_rerio 0 289
ENST00000288986 NCK1-001 protein_coding Homo_sapiens 0 2034
ENST00000460960 NCK1-007 retained_intron Homo_sapiens 0 409
ENST00000467911 NCK1-011 protein_coding Homo_sapiens 0 505
ENST00000469404 NCK1-002 protein_coding Homo_sapiens 0 1687
ENST00000476286 NCK1-006 protein_coding Homo_sapiens 0 348
ENST00000478862 NCK1-008 retained_intron Homo_sapiens 0 355
ENST00000481752 NCK1-003 protein_coding Homo_sapiens 0 2143
ENST00000482071 NCK1-012 retained_intron Homo_sapiens 0 817
ENST00000485096 NCK1-005 protein_coding Homo_sapiens 0 514
ENST00000488930 NCK1-009 protein_coding Homo_sapiens 0 590
ENST00000491539 NCK1-004 protein_coding Homo_sapiens 0 577
ENST00000496489 NCK1-010 protein_coding Homo_sapiens 0 512

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