C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Parkinson disease (autosomal recessive, juvenile) 2, parkin
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000191124 Park2-001 ENSMUSG00000023826 10090 + 17:10840384-12063361 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000191124
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000191124 2.077±0.90 1.485±0.72 1.263±0.01 1.251±0.79 0.970±0.30 0.310±0.13 0.807±0.43 1.780±0.49 0.365±0.33 1.189±0.06 1.318±0.38 1.436±0.63 0.158±0.10 6.147±2.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AN CIL_0009AN_0002 VISTA 17:10443926-11046179
CIL_000800 CIL_000800_0002 VISTA 17:10785724-11388280

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000151 IEA ubiquitin ligase complex
GO:0000209 ISS protein polyubiquitination
GO:0000266 ISS mitochondrial fission
GO:0000422 ISS mitochondrion degradation
GO:0001664 IEA G-protein coupled receptor binding
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0001964 IMP startle response
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 ISS mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 ISS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006513 ISS protein monoubiquitination
GO:0006979 ISS response to oxidative stress
GO:0007005 ISS mitochondrion organization
GO:0007612 IMP learning
GO:0007626 IMP locomotory behavior
GO:0008270 IEA zinc ion binding
GO:0008344 IMP adult locomotory behavior
GO:0010506 ISS regulation of autophagy
GO:0010636 IEA positive regulation of mitochondrial fusion
GO:0010637 ISS negative regulation of mitochondrial fusion
GO:0010821 ISS regulation of mitochondrion organization
GO:0016235 IEA aggresome
GO:0016567 ISS protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019538 IMP protein metabolic process
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0030054 IEA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030544 IEA Hsp70 protein binding
GO:0031072 IEA heat shock protein binding
GO:0031624 IEA ubiquitin conjugating enzyme binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032232 IEA negative regulation of actin filament bundle assembly
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132 IEA negative regulation of glucokinase activity
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035249 IMP synaptic transmission, glutamatergic
GO:0042415 IMP norepinephrine metabolic process
GO:0042417 IMP dopamine metabolic process
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IEA identical protein binding
GO:0043005 IDA neuron projection
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ISS ubiquitin binding
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043234 IDA protein complex
GO:0043388 IEA positive regulation of DNA binding
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0044257 IMP cellular protein catabolic process
GO:0045211 IEA postsynaptic membrane
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 ISS negative regulation of JNK cascade
GO:0046676 IEA negative regulation of insulin secretion
GO:0046928 IMP regulation of neurotransmitter secretion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050804 IMP regulation of synaptic transmission
GO:0051087 IEA chaperone binding
GO:0051583 IMP dopamine uptake involved in synaptic transmission
GO:0051865 ISS protein autoubiquitination
GO:0055069 ISS zinc ion homeostasis
GO:0060548 IEA negative regulation of cell death
GO:0061630 IEA ubiquitin protein ligase activity
GO:0070050 ISS neuron cellular homeostasis
GO:0070534 IEA protein K63-linked ubiquitination
GO:0070585 IMP protein localization to mitochondrion
GO:0070842 IEA aggresome assembly
GO:0070936 ISS protein K48-linked ubiquitination
GO:0071797 IEA LUBAC complex
GO:0090141 ISS positive regulation of mitochondrial fission
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:0097237 IDA cellular response to toxic substance
GO:0097602 IEA cullin family protein binding
GO:1900407 ISS regulation of cellular response to oxidative stress
GO:1901215 IMP negative regulation of neuron death
GO:1901800 IEA positive regulation of proteasomal protein catabolic process
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902530 IMP positive regulation of protein linear polyubiquitination
GO:1903265 IEA positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903377 IEA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378 IMP positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382 IMP negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IEA ubiquitin-specific protease binding
GO:1990444 IEA F-box domain binding
GO:1990452 IEA Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000377 IEA regulation of reactive oxygen species metabolic process
GO:2000378 IEA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000338468 PARK2-003 protein_coding Homo_sapiens 0 922
ENST00000366892 PARK2-002 protein_coding Homo_sapiens 0 1051
ENST00000366894 PARK2-001 protein_coding Homo_sapiens 0 1000
ENST00000366896 PARK2-006 protein_coding Homo_sapiens 0 821
ENST00000366897 PARK2-005 protein_coding Homo_sapiens 0 821
ENST00000366898 PARK2-004 protein_coding Homo_sapiens 0 1360
ENST00000479615 PARK2-007 nonsense_mediated_decay Homo_sapiens 0 544
ENST00000610470 PARK2-201 protein_coding Homo_sapiens 0 556
ENST00000612485 PARK2-202 protein_coding Homo_sapiens 0 252

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