C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: chemokine (C-X-C motif) receptor 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000241393 CXCR4-001 ENSG00000121966 9606 - 2:136114351-136118165 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000241393
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000241393 30.603±0.00 179.648±0.00 1.327±0.05 6.537±0.08 5.842±2.40 1.539±0.73 3.437±1.76 6.253±2.18 39.318±19.95 1.629±0.35 15.105±8.51 23.372±3.01 7.606±1.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00077L CIL_00077L_0001 CGP 2:135906677-136118165
CIL_0006VZ CIL_0006VZ_0001 CGP 2:136114349-137677717

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001618 IEA virus receptor activity
GO:0001666 IEP response to hypoxia
GO:0002407 TAS dendritic cell chemotaxis
GO:0003779 IDA actin binding
GO:0004930 TAS:IEA G-protein coupled receptor activity
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005764 IDA lysosome
GO:0005769 IDA early endosome
GO:0005770 IDA late endosome
GO:0005886 IDA plasma membrane
GO:0006915 TAS apoptotic process
GO:0006954 TAS inflammatory response
GO:0007186 IDA:IEA G-protein coupled receptor signaling pathway
GO:0007204 TAS positive regulation of cytosolic calcium ion concentration
GO:0009615 TAS response to virus
GO:0009986 IDA cell surface
GO:0015026 TAS coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016032 TAS viral process
GO:0016494 NAS C-X-C chemokine receptor activity
GO:0019722 IMP calcium-mediated signaling
GO:0019955 IEA cytokine binding
GO:0030260 TAS entry into host cell
GO:0031252 IDA cell leading edge
GO:0031410 IDA cytoplasmic vesicle
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032027 IDA myosin light chain binding
GO:0042119 IEA neutrophil activation
GO:0043130 IDA ubiquitin binding
GO:0043217 ISS myelin maintenance
GO:0048714 ISS positive regulation of oligodendrocyte differentiation
GO:0050920 IMP regulation of chemotaxis
GO:0070062 IDA extracellular vesicular exosome
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0071345 IDA cellular response to cytokine stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000052172 Cxcr4-001 protein_coding Mus_musculus 0 1253
ENSMUST00000142893 Cxcr4-002 protein_coding Mus_musculus 0 865

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