C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: platelet-derived growth factor receptor, alpha polypeptide
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000257290 PDGFRA-001 ENSG00000134853 9606 + 4:54229097-54298247 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257290
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257290 10.959±0.00 5.721±1.62 8.378±0.00 12.411±4.75 4.723±1.61 4.446±0.00 22.616±0.00 13.010±8.31 1.719±0.49 26.966±8.20 12.258±4.37 5.769±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CS CIL_0001CS_0001 CGP 4:52872982-54295272
CIL_0001CL CIL_0001CL_0001 CGP 4:53377643-54295272
CIL_0007R1 CIL_0007R1_0001 VISTA 4:53715055-54316288
CIL_0008IT CIL_0008IT_0001 VISTA 4:53795831-54396629
CIL_0001CO CIL_0001CO_0001 CGP 4:54099523-54298247
CIL_0001CJ CIL_0001CJ_0001 CGP 4:54229097-54740715

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001553 ISS luteinization
GO:0001701 IEA in utero embryonic development
GO:0001775 TAS cell activation
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IDA:IEA transmembrane receptor protein tyrosine kinase activity
GO:0005018 IDA platelet-derived growth factor alpha-receptor activity
GO:0005021 IDA vascular endothelial growth factor-activated receptor activity
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005902 IEA microvillus
GO:0006468 IEA protein phosphorylation
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007204 IMP positive regulation of cytosolic calcium ion concentration
GO:0008210 IEA estrogen metabolic process
GO:0008284 IMP positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008585 IEA female gonad development
GO:0009653 IEA anatomical structure morphogenesis
GO:0009887 IEA organ morphogenesis
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010544 IDA negative regulation of platelet activation
GO:0010863 IMP positive regulation of phospholipase C activity
GO:0014068 TAS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030198 IEA extracellular matrix organization
GO:0030324 IEA lung development
GO:0030325 IEA adrenal gland development
GO:0030335 IMP positive regulation of cell migration
GO:0030539 IEA male genitalia development
GO:0031226 IDA intrinsic component of plasma membrane
GO:0033327 IEA Leydig cell differentiation
GO:0035790 IMP platelet-derived growth factor receptor-alpha signaling pathway
GO:0038085 IPI vascular endothelial growth factor binding
GO:0038091 IDA positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 ISS wound healing
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042803 IDA protein homodimerization activity
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045740 IDA positive regulation of DNA replication
GO:0046777 IDA protein autophosphorylation
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 IMP phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048407 IPI platelet-derived growth factor binding
GO:0048557 ISS embryonic digestive tract morphogenesis
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048704 ISS embryonic skeletal system morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0050920 IMP regulation of chemotaxis
GO:0055003 ISS cardiac myofibril assembly
GO:0060021 IEA palate development
GO:0060325 IEA face morphogenesis
GO:0060326 IMP cell chemotaxis
GO:0061298 ISS retina vasculature development in camera-type eye
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070527 IMP platelet aggregation
GO:0071230 IEA cellular response to amino acid stimulus
GO:0072277 ISS metanephric glomerular capillary formation
GO:2000249 TAS regulation of actin cytoskeleton reorganization
GO:2000739 IMP regulation of mesenchymal stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000000476 Pdgfra-201 protein_coding Mus_musculus 0 4224
ENSMUST00000168162 Pdgfra-202 protein_coding Mus_musculus 0 4124
ENSDART00000028255 pdgfrb-201 protein_coding Danio_rerio 2.8026e-45 189
ENSDART00000081357 flt3-001 protein_coding Danio_rerio 1e-19 104

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