C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000262215 ARFGEF1-001 ENSG00000066777 9606 - 8:67197649-67343677 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000262215
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000262215 1.913±0.00 2.551±0.00 3.768±0.00 2.178±0.00 4.591±0.00 4.796±1.37 1.949±0.45 2.638±0.69 2.672±1.39 3.103±0.00 3.778±2.43 4.084±1.53 16.330±4.68

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003BF CIL_0003BF_0001 CGP 8:67043079-67196263
CIL_0001S0 CIL_0001S0_0002 CGP 8:67062426-67343677
CIL_0005BT CIL_0005BT_0002 CGP 8:67173512-67746345

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 IDA Golgi membrane
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005086 IBA:IEA ARF guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005802 ISS trans-Golgi network
GO:0005829 IDA cytosol
GO:0006887 TAS exocytosis
GO:0007030 IMP Golgi organization
GO:0010256 IMP endomembrane system organization
GO:0015031 IEA protein transport
GO:0016192 IBA vesicle-mediated transport
GO:0017022 IPI myosin binding
GO:0030532 IDA small nuclear ribonucleoprotein complex
GO:0030837 IMP negative regulation of actin filament polymerization
GO:0032012 IEA regulation of ARF protein signal transduction
GO:0034237 IDA protein kinase A regulatory subunit binding
GO:0034259 IDA negative regulation of Rho GTPase activity
GO:0043547 IEA positive regulation of GTPase activity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0090284 IMP positive regulation of protein glycosylation in Golgi
GO:0090303 IMP positive regulation of wound healing
GO:2000114 IMP regulation of establishment of cell polarity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000088615 Arfgef1-002 protein_coding Mus_musculus 0 8342
ENSMUST00000131556 Arfgef1-001 protein_coding Mus_musculus 0 4525
ENSMUST00000186720 Arfgef1-007 retained_intron Mus_musculus 0 765
ENSMUST00000142497 Arfgef1-005 retained_intron Mus_musculus 0 741
ENSMUST00000187417 Arfgef1-008 retained_intron Mus_musculus 0 645
ENSMUST00000156563 Arfgef1-003 retained_intron Mus_musculus 0 449
ENSMUST00000186813 Arfgef1-006 retained_intron Mus_musculus 0 368
ENSMUST00000128834 Arfgef1-004 retained_intron Mus_musculus 0 235

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