C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000264867 PPARGC1A-001 ENSG00000109819 9606 - 4:23792021-23890077 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264867
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264867 1.030±0.00 1.111±0.00 12.005±0.00 2.330±0.80 0.378±0.00 2.128±0.00 8.293±5.05 7.411±4.14 0.772±0.01 0.628±0.00 3.904±0.00 1.345±0.80 0.034±0.02 0.321±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OU CIL_0002OU_0001 CGP 4:22345071-23904089
CIL_0007ZS CIL_0007ZS_0001 VISTA 4:23630438-24232069
CIL_00033R CIL_00033R_0002 CGP 4:23755041-24584550

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0001104 TAS RNA polymerase II transcription cofactor activity
GO:0001659 TAS temperature homeostasis
GO:0001666 IEA response to hypoxia
GO:0001678 NAS cellular glucose homeostasis
GO:0003676 IEA nucleic acid binding
GO:0003677 ISS DNA binding
GO:0003682 IEA chromatin binding
GO:0003713 IDA transcription coactivator activity
GO:0003723 TAS RNA binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005665 TAS DNA-directed RNA polymerase II, core complex
GO:0005829 IEA cytosol
GO:0006012 IEA galactose metabolic process
GO:0006094 NAS gluconeogenesis
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006397 TAS mRNA processing
GO:0006461 TAS protein complex assembly
GO:0007005 NAS mitochondrion organization
GO:0007586 TAS digestion
GO:0008134 TAS transcription factor binding
GO:0008209 IEA androgen metabolic process
GO:0008380 TAS RNA splicing
GO:0009409 IEA response to cold
GO:0010822 ISS positive regulation of mitochondrion organization
GO:0014070 IEA response to organic cyclic compound
GO:0014823 IEA response to activity
GO:0014850 ISS response to muscle activity
GO:0016922 IPI ligand-dependent nuclear receptor binding
GO:0019395 NAS fatty acid oxidation
GO:0022904 ISS respiratory electron transport chain
GO:0030374 IDA ligand-dependent nuclear receptor transcription coactivator activity
GO:0030521 NAS androgen receptor signaling pathway
GO:0031325 IEA positive regulation of cellular metabolic process
GO:0031490 ISS chromatin DNA binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031667 IEA response to nutrient levels
GO:0032922 ISS circadian regulation of gene expression
GO:0034599 ISS cellular response to oxidative stress
GO:0035066 TAS positive regulation of histone acetylation
GO:0036273 IEA response to statin
GO:0042493 IEA response to drug
GO:0042594 NAS response to starvation
GO:0042752 ISS regulation of circadian rhythm
GO:0043201 IEA response to leucine
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0045333 TAS cellular respiration
GO:0045722 TAS positive regulation of gluconeogenesis
GO:0045820 IEA negative regulation of glycolytic process
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046321 TAS positive regulation of fatty acid oxidation
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050681 NAS androgen receptor binding
GO:0050821 TAS protein stabilization
GO:0050873 TAS brown fat cell differentiation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051552 IEA flavone metabolic process
GO:0071250 IEA cellular response to nitrite
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071398 IEA cellular response to fatty acid
GO:0071456 IEA cellular response to hypoxia
GO:0071871 IEA response to epinephrine
GO:0071873 IEA response to norepinephrine
GO:0097067 IEA cellular response to thyroid hormone stimulus
GO:1901215 IGI negative regulation of neuron death
GO:1901857 IEA positive regulation of cellular respiration
GO:1901860 IEA positive regulation of mitochondrial DNA metabolic process
GO:1901863 IEA positive regulation of muscle tissue development
GO:2000272 IEA negative regulation of receptor activity
GO:2000310 IEA regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000507 ISS positive regulation of energy homeostasis
GO:2001171 ISS positive regulation of ATP biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000132734 Ppargc1a-001 protein_coding Mus_musculus 0 4041
ENSMUST00000031059 Ppargc1a-002 nonsense_mediated_decay Mus_musculus 0 2453
ENSMUST00000151104 Ppargc1a-003 protein_coding Mus_musculus 0 1081
ENSMUST00000127135 Ppargc1a-004 protein_coding Mus_musculus 0 403

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