C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: signal transducer and activator of transcription 1, 91kDa
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000361099 STAT1-001 ENSG00000115415 9606 - 2:190969034-191014250 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361099
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361099 13.667±0.00 19.950±0.00 21.345±0.00 20.212±4.54 9.999±2.16 8.947±6.21 15.052±3.94 9.156±0.57 22.214±8.47 4.317±3.50 19.932±5.04 24.169±10.07 13.136±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AM CIL_0009AM_0001 VISTA 2:190761403-191362006

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983 IDA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001937 IMP negative regulation of endothelial cell proliferation
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0003340 ISS negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003677 IEA DNA binding
GO:0003690 IDA double-stranded DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005164 IPI tumor necrosis factor receptor binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006915 ISS apoptotic process
GO:0007165 IEA signal transduction
GO:0007259 IDA JAK-STAT cascade
GO:0007584 IEA response to nutrient
GO:0008015 ISS blood circulation
GO:0008284 IEA positive regulation of cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009617 IEA response to bacterium
GO:0014070 IEA response to organic cyclic compound
GO:0016032 IEA viral process
GO:0016525 IMP negative regulation of angiogenesis
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019899 IPI enzyme binding
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032496 IEA response to lipopolysaccharide
GO:0032869 IEA cellular response to insulin stimulus
GO:0033209 IDA tumor necrosis factor-mediated signaling pathway
GO:0034097 ISS response to cytokine
GO:0034240 IEA negative regulation of macrophage fusion
GO:0035458 IMP cellular response to interferon-beta
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0042981 TAS regulation of apoptotic process
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 IEA response to exogenous dsRNA
GO:0043434 ISS response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0051591 ISS response to cAMP
GO:0051607 IEA defense response to virus
GO:0060333 ISS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0060337 ISS type I interferon signaling pathway
GO:0060338 TAS regulation of type I interferon-mediated signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0061326 IMP renal tubule development
GO:0072136 ISS metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 ISS metanephric mesenchymal cell differentiation
GO:0072308 ISS negative regulation of metanephric nephron tubule epithelial cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000186857 Stat1-006 protein_coding Mus_musculus 0 2627
ENSMUST00000070968 Stat1-001 protein_coding Mus_musculus 0 2627
ENSMUST00000186057 Stat1-009 protein_coding Mus_musculus 0 2549
ENSMUST00000189347 Stat1-008 protein_coding Mus_musculus 0 2359
ENSMUST00000191435 Stat1-007 protein_coding Mus_musculus 0 2359
ENSMUST00000186574 Stat1-004 protein_coding Mus_musculus 0 2359
ENSMUST00000189244 Stat1-010 protein_coding Mus_musculus 0 953
ENSMUST00000189336 Stat1-015 nonsense_mediated_decay Mus_musculus 0 501
ENSMUST00000189075 Stat1-014 retained_intron Mus_musculus 0 357
ENSMUST00000138438 Stat3-011 protein_coding Mus_musculus 0.0000000000001 84
ENSMUST00000092671 Stat3-010 protein_coding Mus_musculus 0.0000000000001 84
ENSMUST00000127638 Stat3-001 protein_coding Mus_musculus 0.0000000000001 84
ENSMUST00000103114 Stat3-002 protein_coding Mus_musculus 0.0000000000001 84
ENSMUST00000156645 Stat3-003 processed_transcript Mus_musculus 0.0000000000004 82

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