C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor 7-like 2 (T-cell specific, HMG-box)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000369397 TCF7L2-003 ENSG00000148737 9606 + 10:112950452-113167678 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonLiverOvaryPlacentaTestisENST00000369397
Transcript ID Adipose Adrenal Brain Breast Colon Liver Ovary Placenta Testis
ENST00000369397 12.773±0.00 2.981±0.00 2.839±0.00 7.548±0.00 10.156±0.00 1.501±0.00 5.702±0.75 3.162±1.28 12.591±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OU CIL_0006OU_0001 CGP 10:112446998-113167678
CIL_0007PE CIL_0007PE_0001 UCNEbase 10:112490627-113337047
CIL_0006OX CIL_0006OX_0001 CGP 10:112950250-113589602

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001568 IMP blood vessel development
GO:0003682 IBA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IBA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005977 IEA glycogen metabolic process
GO:0006006 IEA glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0007050 IMP cell cycle arrest
GO:0007420 IBA brain development
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008283 IMP cell proliferation
GO:0009267 IEA cellular response to starvation
GO:0009749 ISS response to glucose
GO:0009791 IEA post-embryonic development
GO:0010867 IEA positive regulation of triglyceride biosynthetic process
GO:0010909 IMP positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 IEA oligodendrocyte development
GO:0016055 IEA Wnt signaling pathway
GO:0019901 IPI protein kinase binding
GO:0021915 IEA neural tube development
GO:0021983 IEA pituitary gland development
GO:0030282 IEA bone mineralization
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030538 IEA embryonic genitalia morphogenesis
GO:0031016 TAS pancreas development
GO:0031641 IEA regulation of myelination
GO:0032024 IDA positive regulation of insulin secretion
GO:0032092 IDA positive regulation of protein binding
GO:0032252 IEA secretory granule localization
GO:0032350 IDA regulation of hormone metabolic process
GO:0032993 IDA protein-DNA complex
GO:0035019 IEA somatic stem cell maintenance
GO:0035257 IPI nuclear hormone receptor binding
GO:0035264 IEA multicellular organism growth
GO:0035411 IEA catenin import into nucleus
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042593 IDA glucose homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0043570 IMP maintenance of DNA repeat elements
GO:0043588 IEA skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044334 IMP canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 IPI gamma-catenin binding
GO:0045444 IDA fat cell differentiation
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046621 IEA negative regulation of organ growth
GO:0046827 IMP positive regulation of protein export from nucleus
GO:0046889 IEA positive regulation of lipid biosynthetic process
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048619 IEA embryonic hindgut morphogenesis
GO:0048625 IDA myoblast fate commitment
GO:0048641 IEA regulation of skeletal muscle tissue development
GO:0048660 IMP regulation of smooth muscle cell proliferation
GO:0048699 IBA generation of neurons
GO:0048713 IEA regulation of oligodendrocyte differentiation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0060070 IC canonical Wnt signaling pathway
GO:0060325 IEA face morphogenesis
GO:0061178 IEA regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070016 IPI armadillo repeat domain binding
GO:0070369 IDA beta-catenin-TCF7L2 complex
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:1901142 IEA insulin metabolic process
GO:2000675 IDA negative regulation of type B pancreatic cell apoptotic process
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000111657 Tcf7l2-202 protein_coding Mus_musculus 0 4373
ENSMUST00000111656 Tcf7l2-006 protein_coding Mus_musculus 0 3951
ENSMUST00000111646 Tcf7l2-007 protein_coding Mus_musculus 0 2907
ENSMUST00000061496 Tcf7l2-201 protein_coding Mus_musculus 0 2139
ENSMUST00000111662 Tcf7l2-203 protein_coding Mus_musculus 0 2030
ENSMUST00000041717 Tcf7l2-012 protein_coding Mus_musculus 0 2030
ENSMUST00000111659 Tcf7l2-009 protein_coding Mus_musculus 0 1958
ENSMUST00000127233 Tcf7l2-008 protein_coding Mus_musculus 0 1840
ENSMUST00000111653 Tcf7l2-010 protein_coding Mus_musculus 0 1733
ENSMUST00000111658 Tcf7l2-001 protein_coding Mus_musculus 0 1399
ENSDART00000125046 tcf7l2-008 protein_coding Danio_rerio 0 1376
ENSDART00000031408 tcf7l2-009 protein_coding Danio_rerio 0 1314
ENSDART00000121527 tcf7l2-201 protein_coding Danio_rerio 0 1288
ENSDART00000153068 tcf7l2-001 protein_coding Danio_rerio 0 1277
ENSMUST00000111649 Tcf7l2-002 protein_coding Mus_musculus 0 1256
ENSDART00000005562 tcf7l2-007 protein_coding Danio_rerio 0 1214
ENSMUST00000153888 Tcf7l2-005 protein_coding Mus_musculus 0 1107
ENSMUST00000111654 Tcf7l2-011 protein_coding Mus_musculus 0 1029
ENSMUST00000126434 Tcf7l2-013 retained_intron Mus_musculus 0 987
ENSMUST00000145249 Tcf7l2-019 processed_transcript Mus_musculus 0 931
ENSMUST00000148666 Tcf7l2-015 protein_coding Mus_musculus 0 913
ENSDART00000122972 tcf7l2-006 protein_coding Danio_rerio 0 815
ENSDART00000009237 tcf7l2-002 protein_coding Danio_rerio 0 815
ENSMUST00000111651 Tcf7l2-004 protein_coding Mus_musculus 0 804
ENSMUST00000143334 Tcf7l2-016 processed_transcript Mus_musculus 0 737
ENSMUST00000142291 Tcf7l2-018 protein_coding Mus_musculus 0 732
ENSMUST00000133008 Tcf7l2-014 retained_intron Mus_musculus 0 688
ENSMUST00000111652 Tcf7l2-003 protein_coding Mus_musculus 0 684
ENSMUST00000127653 Tcf7l2-017 processed_transcript Mus_musculus 0 448
ENSDART00000133854 tcf7l2-005 protein_coding Danio_rerio 0 416
ENSDART00000128703 tcf7l2-003 processed_transcript Danio_rerio 0 407
ENSDART00000145967 tcf7l2-004 protein_coding Danio_rerio 0 368

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