C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000372190 RAPGEF1-201 ENSG00000107263 9606 - 9:131576771-131709842 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverOvaryPlacentaTestisENST00000372190
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENST00000372190 14.361±0.00 6.848±0.00 0.827±0.00 0.629±0.00 6.715±0.00 2.084±0.00 1.232±0.00 1.379±0.00 0.947±0.00 3.179±1.40 15.627±6.95 2.671±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088E CIL_00088E_0001 VISTA 9:131030990-131632063
CIL_0002EB CIL_0002EB_0002 CGP 9:131576770-132079908

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000186 TAS activation of MAPKK activity
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005768 TAS endosome
GO:0005769 IDA early endosome
GO:0005829 TAS cytosol
GO:0007165 NAS signal transduction
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0010976 IMP positive regulation of neuron projection development
GO:0017034 IDA Rap guanyl-nucleotide exchange factor activity
GO:0017124 IEA SH3 domain binding
GO:0032486 IMP Rap protein signal transduction
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0038180 IDA nerve growth factor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0061028 IMP establishment of endothelial barrier
GO:0071320 IDA cellular response to cAMP
GO:1901888 IMP regulation of cell junction assembly
GO:1990090 IDA cellular response to nerve growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000102872 Rapgef1-001 protein_coding Mus_musculus 0 3653
ENSMUST00000095087 Rapgef1-007 protein_coding Mus_musculus 0 2043
ENSMUST00000147755 Rapgef1-003 nonsense_mediated_decay Mus_musculus 0 1653
ENSMUST00000091146 Rapgef1-004 protein_coding Mus_musculus 0 1652
ENSMUST00000147488 Rapgef1-002 protein_coding Mus_musculus 0 1611
ENSMUST00000137719 Rapgef1-005 processed_transcript Mus_musculus 0 501

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