C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: optineurin
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378748 OPTN-005 ENSG00000123240 9606 + 10:13100173-13138291 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; LiverENST00000378748
Transcript ID Liver
ENST00000378748 2.097±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004RC CIL_0004RC_0002 CGP 10:12349482-13099652
CIL_0004RD CIL_0004RD_0002 CGP 10:12896625-13138308
CIL_000968 CIL_000968_0001 VISTA 10:13045564-13647145

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000042 IMP protein targeting to Golgi
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000139 TAS Golgi membrane
GO:0000278 TAS mitotic cell cycle
GO:0001920 IMP negative regulation of receptor recycling
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005829 TAS cytosol
GO:0007030 IMP Golgi organization
GO:0007165 TAS signal transduction
GO:0008022 IPI protein C-terminus binding
GO:0008219 IEA cell death
GO:0016236 IDA macroautophagy
GO:0017137 IPI Rab GTPase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031593 IDA polyubiquitin binding
GO:0034613 IEA cellular protein localization
GO:0043001 IMP Golgi to plasma membrane protein transport
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0070530 IEA K63-linked polyubiquitin binding
GO:0090161 IDA Golgi ribbon formation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000114996 Optn-001 protein_coding Mus_musculus 0 1007
ENSMUST00000027986 Optn-002 protein_coding Mus_musculus 0 972
ENSMUST00000145501 Optn-004 processed_transcript Mus_musculus 0 839
ENSMUST00000125203 Optn-003 processed_transcript Mus_musculus 0 785
ENSMUST00000143809 Optn-005 processed_transcript Mus_musculus 0 383

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