C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397033 ITGA4-001 ENSG00000115232 9606 + 2:181457225-181536187 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonKidneyLungOvaryPlacentaENST00000397033
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Kidney Lung Ovary Placenta
ENST00000397033 0.411±0.00 5.097±0.00 0.135±0.00 0.130±0.00 0.402±0.00 1.229±0.90 0.626±0.09 5.379±0.89 0.306±0.05 1.132±0.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BZ CIL_0004BZ_0002 CGP 2:180967248-181536187
CIL_00080Y CIL_00080Y_0001 VISTA 2:181386314-181987082
CIL_0004C0 CIL_0004C0_0002 CGP 2:181457202-181680665

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001968 IEA fibronectin binding
GO:0001974 IEA blood vessel remodeling
GO:0003366 IMP cell-matrix adhesion involved in ameboidal cell migration
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0007155 IEA cell adhesion
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008305 IEA integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016477 IEA cell migration
GO:0030183 IC B cell differentiation
GO:0030198 TAS extracellular matrix organization
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0034669 IDA integrin alpha4-beta7 complex
GO:0035987 IEP endodermal cell differentiation
GO:0043113 IMP receptor clustering
GO:0046872 IEA metal ion binding
GO:0050776 TAS regulation of immune response
GO:0050839 IPI cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0050901 IMP leukocyte tethering or rolling
GO:0060324 IEA face development
GO:0060710 IEA chorio-allantoic fusion
GO:0070062 IDA extracellular vesicular exosome
GO:0072678 IEA T cell migration
GO:0090074 IDA negative regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000099972 Itga4-001 protein_coding Mus_musculus 0 3181
ENSMUST00000135919 Itga4-004 processed_transcript Mus_musculus 0 1712
ENSMUST00000126312 Itga4-005 processed_transcript Mus_musculus 0 1306

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