C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor 7-like 2 (T-cell specific, HMG-box)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000538897 TCF7L2-206 ENSG00000148737 9606 + 10:112950250-113167678 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastOvaryPlacentaENST00000538897
Transcript ID Adipose Bladder Breast Ovary Placenta
ENST00000538897 4.654±0.00 0.841±0.00 0.628±0.00 2.031±0.00 2.658±1.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OU CIL_0006OU_0001 CGP 10:112446998-113167678
CIL_0007PE CIL_0007PE_0001 UCNEbase 10:112490627-113337047
CIL_0006OX CIL_0006OX_0001 CGP 10:112950250-113589602

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001568 IMP blood vessel development
GO:0003682 IBA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IBA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0007050 IMP cell cycle arrest
GO:0007420 IBA brain development
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008283 IMP cell proliferation
GO:0009749 ISS response to glucose
GO:0010909 IMP positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0019901 IPI protein kinase binding
GO:0031016 TAS pancreas development
GO:0032024 IDA positive regulation of insulin secretion
GO:0032092 IDA positive regulation of protein binding
GO:0032350 IDA regulation of hormone metabolic process
GO:0032993 IDA protein-DNA complex
GO:0035257 IPI nuclear hormone receptor binding
GO:0042593 IDA glucose homeostasis
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0043570 IMP maintenance of DNA repeat elements
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044334 IMP canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 IPI gamma-catenin binding
GO:0045444 IDA fat cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046827 IMP positive regulation of protein export from nucleus
GO:0048625 IDA myoblast fate commitment
GO:0048660 IMP regulation of smooth muscle cell proliferation
GO:0048699 IBA generation of neurons
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0060070 IC canonical Wnt signaling pathway
GO:0070016 IPI armadillo repeat domain binding
GO:0070369 IDA beta-catenin-TCF7L2 complex
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:2000675 IDA negative regulation of type B pancreatic cell apoptotic process
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000061496 Tcf7l2-201 protein_coding Mus_musculus 0 3321
ENSMUST00000111654 Tcf7l2-011 protein_coding Mus_musculus 0 2239
ENSMUST00000111657 Tcf7l2-202 protein_coding Mus_musculus 0 2139
ENSMUST00000111656 Tcf7l2-006 protein_coding Mus_musculus 0 2135
ENSMUST00000111658 Tcf7l2-001 protein_coding Mus_musculus 0 2128
ENSMUST00000041717 Tcf7l2-012 protein_coding Mus_musculus 0 1831
ENSMUST00000111662 Tcf7l2-203 protein_coding Mus_musculus 0 1827
ENSMUST00000127233 Tcf7l2-008 protein_coding Mus_musculus 0 1825
ENSMUST00000111646 Tcf7l2-007 protein_coding Mus_musculus 0 1823
ENSMUST00000153888 Tcf7l2-005 protein_coding Mus_musculus 0 1655
ENSMUST00000111652 Tcf7l2-003 protein_coding Mus_musculus 0 1290
ENSMUST00000111653 Tcf7l2-010 protein_coding Mus_musculus 0 1048
ENSMUST00000111659 Tcf7l2-009 protein_coding Mus_musculus 0 1048
ENSMUST00000145249 Tcf7l2-019 processed_transcript Mus_musculus 0 931
ENSMUST00000148666 Tcf7l2-015 protein_coding Mus_musculus 0 913
ENSDART00000125046 tcf7l2-008 protein_coding Danio_rerio 0 846
ENSDART00000153068 tcf7l2-001 protein_coding Danio_rerio 0 846
ENSDART00000031408 tcf7l2-009 protein_coding Danio_rerio 0 784
ENSDART00000005562 tcf7l2-007 protein_coding Danio_rerio 0 784
ENSDART00000121527 tcf7l2-201 protein_coding Danio_rerio 0 769
ENSDART00000122972 tcf7l2-006 protein_coding Danio_rerio 0 758
ENSDART00000009237 tcf7l2-002 protein_coding Danio_rerio 0 758
ENSMUST00000143334 Tcf7l2-016 processed_transcript Mus_musculus 0 737
ENSMUST00000142291 Tcf7l2-018 protein_coding Mus_musculus 0 732
ENSMUST00000126434 Tcf7l2-013 retained_intron Mus_musculus 0 684
ENSMUST00000111651 Tcf7l2-004 protein_coding Mus_musculus 0 684
ENSMUST00000111649 Tcf7l2-002 protein_coding Mus_musculus 0 684
ENSMUST00000133008 Tcf7l2-014 retained_intron Mus_musculus 0 453
ENSMUST00000127653 Tcf7l2-017 processed_transcript Mus_musculus 0 448
ENSDART00000133854 tcf7l2-005 protein_coding Danio_rerio 0 416
ENSDART00000145967 tcf7l2-004 protein_coding Danio_rerio 0 368
ENSDART00000128703 tcf7l2-003 processed_transcript Danio_rerio 0 318

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