C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: estrogen receptor 2 (ER beta)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000557772 ESR2-005 ENSG00000140009 9606 - 14:64230918-64282985 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000557772
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000557772 0.057±0.00 0.132±0.00 0.266±0.00 0.560±0.00 0.060±0.00 0.075±0.01 0.254±0.20 0.037±0.00 0.086±0.00 0.127±0.01 0.588±0.00 0.032±0.02 1.071±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004WO CIL_0004WO_0001 CGP 14:63684214-64226433
CIL_00010O CIL_00010O_0001 CGP 14:63852983-64338112

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0003677 TAS DNA binding
GO:0003700 IEA:TAS sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:TAS steroid hormone receptor activity
GO:0003713 TAS transcription coactivator activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 IEA:ISS steroid binding
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005634 IEA:TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005739 IDA mitochondrion
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA:TAS regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0019899 IPI enzyme binding
GO:0030284 TAS estrogen receptor activity
GO:0030308 NAS negative regulation of cell growth
GO:0030520 TAS intracellular estrogen receptor signaling pathway
GO:0034056 IDA estrogen response element binding
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0048019 NAS receptor antagonist activity
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:1900116 NAS extracellular negative regulation of signal transduction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000076634 Esr2-201 protein_coding Mus_musculus 0 1367
ENSMUST00000110421 Esr2-001 protein_coding Mus_musculus 0 1367
ENSMUST00000101291 Esr2-002 protein_coding Mus_musculus 0 1092
ENSMUST00000133564 Esr2-003 nonsense_mediated_decay Mus_musculus 0 902

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