C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005884 ITGA3 9606 + 17:50055968-50090481 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000007722 ITGA3-020 50056440-50089729 protein_coding
  ENST00000320031 ITGA3-001 50056110-50090480 protein_coding
  ENST00000504417 ITGA3-018 50080317-50081380 nonsense_mediated_decay
  ENST00000505306 ITGA3-002 50056068-50090480 retained_intron
  ENST00000505552 ITGA3-011 50071740-50074211 retained_intron
  ENST00000505612 ITGA3-013 50075460-50076733 retained_intron
  ENST00000506401 ITGA3-003 50055968-50076995 nonsense_mediated_decay
  ENST00000506437 ITGA3-006 50086329-50090481 retained_intron
  ENST00000506827 ITGA3-014 50076625-50090481 protein_coding
  ENST00000507771 ITGA3-015 50077400-50079016 retained_intron
  ENST00000508100 ITGA3-009 50056487-50064789 retained_intron
  ENST00000510809 ITGA3-012 50072160-50075700 nonsense_mediated_decay
  ENST00000512553 ITGA3-010 50070873-50074514 protein_coding
  ENST00000514834 ITGA3-017 50088213-50089815 retained_intron
  ENST00000515147 ITGA3-016 50078004-50079483 retained_intron
  ENST00000570989 ITGA3-019 50063538-50066032 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000007722ENST00000320031ENST00000505306ENST00000506437ENST00000506827ENST00000514834
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000007722 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.487±0.00 2.591±0.00 N/A N/A
ENST00000320031 9.513±0.00 10.566±0.00 3.534±0.00 4.929±2.34 3.245±1.22 3.658±0.00 29.646±0.00 0.268±0.00 22.775±18.96 4.462±0.00 14.427±7.38 35.017±4.69 6.081±0.00
ENST00000505306 N/A N/A N/A N/A 1.209±0.00 N/A N/A N/A N/A N/A 1.799±0.00 N/A N/A
ENST00000506437 N/A N/A 1.261±0.00 0.693±0.00 N/A N/A 0.028±0.00 0.775±0.69 N/A 0.092±0.00 1.811±0.00 N/A 0.539±0.00
ENST00000506827 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.306±0.00 N/A N/A N/A
ENST00000514834 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.431±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QJ CIL_0007QJ_0001 VISTA 17:49459872-50061823
CIL_00088W CIL_00088W_0001 VISTA 17:49956976-50560219
CIL_0004N5 CIL_0004N5_0002 CGP 17:49990005-50090481

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 IEA neuron migration
GO:0001948 IPI glycoprotein binding
GO:0001968 IEA fibronectin binding
GO:0002020 IPI protease binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005518 IEA collagen binding
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0007155 IEA cell adhesion
GO:0007160 TAS cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0007613 IEA memory
GO:0008305 TAS integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010628 IEA positive regulation of gene expression
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0010976 IEA positive regulation of neuron projection development
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0019904 IEA protein domain specific binding
GO:0030111 IMP regulation of Wnt signaling pathway
GO:0030198 TAS extracellular matrix organization
GO:0030324 IMP lung development
GO:0030426 IEA growth cone
GO:0030510 IMP regulation of BMP signaling pathway
GO:0031345 IEA negative regulation of cell projection organization
GO:0031527 IDA filopodium membrane
GO:0034667 IMP integrin alpha3-beta1 complex
GO:0034698 IEA response to gonadotropin
GO:0035024 IEA negative regulation of Rho protein signal transduction
GO:0035640 IEA exploration behavior
GO:0042493 IEA response to drug
GO:0043235 IDA receptor complex
GO:0043236 IEA laminin binding
GO:0043588 IMP skin development
GO:0044708 IEA single-organism behavior
GO:0045202 IEA synapse
GO:0046872 IEA metal ion binding
GO:0046982 IDA protein heterodimerization activity
GO:0048333 IEP mesodermal cell differentiation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050900 TAS leukocyte migration
GO:0060076 IEA excitatory synapse
GO:0060135 IEA maternal process involved in female pregnancy
GO:0070062 IDA extracellular vesicular exosome
GO:0071438 IDA invadopodium membrane
GO:0071944 IDA cell periphery
GO:0072006 IMP nephron development
GO:0090004 IDA positive regulation of establishment of protein localization to plasma membrane
GO:0097060 IEA synaptic membrane
GO:0097062 IEA dendritic spine maintenance
GO:0097205 IMP renal filtration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012824 itga3b integrin, alpha 3b protein_coding Danio_rerio
ENSDARG00000037917 itga3a integrin, alpha 3a protein_coding Danio_rerio
ENSMUSG00000001507 Itga3 integrin alpha 3 protein_coding Mus_musculus

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