C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005961 ITGA2B 9606 - 17:44372180-44389505 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262407 ITGA2B-001 44372183-44389505 protein_coding
  ENST00000587295 ITGA2B-011 44372181-44376184 protein_coding
  ENST00000588098 ITGA2B-012 44372180-44374695 protein_coding
  ENST00000589645 ITGA2B-009 44383764-44385363 retained_intron
  ENST00000591990 ITGA2B-007 44383683-44385195 retained_intron
  ENST00000592075 ITGA2B-008 44383938-44385202 retained_intron
  ENST00000592226 ITGA2B-004 44380057-44385202 retained_intron
  ENST00000592253 ITGA2B-006 44383938-44385341 retained_intron
  ENST00000592462 ITGA2B-003 44373924-44383497 retained_intron
  ENST00000592944 ITGA2B-005 44384321-44385809 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262407ENST00000587295ENST00000588098ENST00000589645ENST00000592226ENST00000592253ENST00000592462ENST00000592944
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262407 1.052±0.00 0.256±0.00 0.041±0.00 0.199±0.16 0.234±0.00 0.231±0.12 0.088±0.00 0.073±0.00 0.021±0.00 2.701±2.49 N/A 0.157±0.09 0.580±0.06 0.810±0.08
ENST00000587295 N/A N/A N/A N/A 0.493±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000588098 N/A N/A N/A N/A N/A N/A 0.173±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000589645 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.400±0.00 N/A N/A
ENST00000592226 N/A N/A N/A N/A N/A 0.050±0.00 N/A 0.176±0.00 N/A N/A 0.092±0.00 0.201±0.01 N/A N/A
ENST00000592253 N/A N/A 1.235±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000592462 N/A 0.176±0.00 N/A 0.229±0.00 0.186±0.00 N/A 0.044±0.00 0.256±0.00 0.308±0.00 N/A N/A 0.169±0.10 N/A 0.446±0.00
ENST00000592944 N/A N/A N/A N/A N/A N/A 0.254±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B6 CIL_0009B6_0001 VISTA 17:43966083-44567774
CIL_0007ST CIL_0007ST_0001 VISTA 17:44247434-44848646
CIL_0004D6 CIL_0004D6_0002 CGP 17:44353215-44389505
CIL_0005IZ CIL_0005IZ_0001 CGP 17:44372180-44503430

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0002687 IEA positive regulation of leukocyte migration
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005925 IEA focal adhesion
GO:0007155 TAS cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008305 IEA integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0031092 TAS platelet alpha granule membrane
GO:0042802 IPI identical protein binding
GO:0046872 IEA metal ion binding
GO:0050840 IEA extracellular matrix binding
GO:0070051 IEA fibrinogen binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070527 IEA platelet aggregation
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018687 itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) protein_coding Danio_rerio
ENSMUSG00000034664 Itga2b integrin alpha 2b protein_coding Mus_musculus

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