C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, alpha type, 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000041357 PSMA4 9606 + 15:78540405-78552419 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000044462 PSMA4-001 78540413-78552419 protein_coding
  ENST00000413382 PSMA4-004 78540427-78549204 protein_coding
  ENST00000557929 PSMA4-005 78540467-78546610 processed_transcript
  ENST00000558094 PSMA4-021 78544645-78548996 protein_coding
  ENST00000558281 PSMA4-019 78540478-78548970 protein_coding
  ENST00000558341 PSMA4-017 78540814-78549176 protein_coding
  ENST00000558635 PSMA4-008 78540459-78542559 retained_intron
  ENST00000558639 PSMA4-010 78540444-78544932 retained_intron
  ENST00000559082 PSMA4-006 78540421-78549186 protein_coding
  ENST00000559146 PSMA4-018 78540440-78546696 protein_coding
  ENST00000559154 PSMA4-020 78544576-78546698 protein_coding
  ENST00000559365 PSMA4-015 78540735-78548820 protein_coding
  ENST00000559437 PSMA4-016 78540847-78546696 protein_coding
  ENST00000559906 PSMA4-013 78543818-78545677 processed_transcript
  ENST00000559934 PSMA4-002 78540444-78548906 retained_intron
  ENST00000559948 PSMA4-014 78540427-78546684 protein_coding
  ENST00000560033 PSMA4-007 78540427-78542683 retained_intron
  ENST00000560099 PSMA4-003 78540461-78549204 retained_intron
  ENST00000560217 PSMA4-009 78540405-78549037 protein_coding
  ENST00000560737 PSMA4-012 78541690-78548868 protein_coding
  ENST00000560842 PSMA4-011 78541556-78542375 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000044462ENST00000413382ENST00000557929ENST00000558281ENST00000558341ENST00000559082ENST00000559146ENST00000559934ENST00000559948ENST00000560217ENST00000560737
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000044462 N/A N/A N/A N/A N/A N/A 0.834±0.26 N/A N/A N/A N/A N/A N/A N/A
ENST00000413382 28.161±0.00 42.355±0.00 0.959±0.00 16.964±10.72 41.437±0.00 23.506±21.07 3.883±2.73 15.067±11.65 19.628±0.00 10.214±3.72 N/A 24.948±15.78 8.987±0.70 72.021±0.00
ENST00000557929 N/A N/A N/A 7.839±0.00 8.231±0.00 8.003±0.00 4.146±0.00 N/A N/A 15.080±0.00 N/A 17.143±7.15 11.844±0.00 N/A
ENST00000558281 10.195±0.00 17.692±0.00 3.139±0.00 9.063±4.19 N/A 18.489±0.00 9.094±0.00 10.742±3.95 N/A N/A 9.015±0.00 6.896±0.00 N/A N/A
ENST00000558341 9.179±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 25.116±0.00 N/A
ENST00000559082 6.511±0.00 25.491±0.00 1.667±0.00 2.257±0.00 16.474±8.30 2.869±0.00 8.483±7.14 26.376±0.00 15.934±12.04 26.657±0.00 9.800±7.44 34.837±23.22 29.298±5.43 47.460±12.01
ENST00000559146 N/A N/A 2.381±0.00 7.488±0.00 9.917±0.00 13.494±0.00 5.622±0.00 20.143±0.00 15.781±0.00 7.455±0.00 N/A 18.217±0.00 N/A N/A
ENST00000559934 N/A N/A 0.533±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000559948 13.215±0.00 N/A N/A 21.627±0.00 N/A 24.698±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000560217 N/A N/A N/A N/A N/A 2.836±0.00 6.304±0.00 7.129±0.00 8.123±0.00 13.566±0.00 7.413±4.11 29.982±0.00 30.429±0.00 21.631±0.00
ENST00000560737 N/A N/A N/A N/A N/A N/A 3.363±0.00 N/A N/A N/A 9.913±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003TW CIL_0003TW_0001 CGP 15:78540405-78595269

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0000932 ISS cytoplasmic mRNA processing body
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 IEA endopeptidase activity
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005839 ISS:IEA proteasome core complex
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019773 IEA proteasome core complex, alpha-subunit complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045928 psma4 proteasome (prosome, macropain) subunit, alpha type, 4 protein_coding Danio_rerio
ENSMUSG00000032301 Psma4 proteasome (prosome, macropain) subunit, alpha type 4 protein_coding Mus_musculus

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