C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000071564 TCF3 9606 - 19:1609290-1652605 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262965 TCF3-201 1609290-1652329 protein_coding
  ENST00000344749 TCF3-202 1609290-1652329 protein_coding
  ENST00000395423 TCF3-003 1611249-1652604 protein_coding
  ENST00000453954 TCF3-008 1609293-1652591 protein_coding
  ENST00000585731 TCF3-005 1610965-1615798 protein_coding
  ENST00000585855 TCF3-015 1611314-1619150 nonsense_mediated_decay
  ENST00000586164 TCF3-011 1611755-1615798 nonsense_mediated_decay
  ENST00000586318 TCF3-007 1632051-1651356 protein_coding
  ENST00000586410 TCF3-016 1615811-1621046 protein_coding
  ENST00000587235 TCF3-017 1622324-1652605 protein_coding
  ENST00000587425 TCF3-013 1609472-1615804 protein_coding
  ENST00000588136 TCF3-002 1611168-1650745 protein_coding
  ENST00000590436 TCF3-009 1611168-1619853 protein_coding
  ENST00000590605 TCF3-018 1615791-1621206 retained_intron
  ENST00000590684 TCF3-004 1611056-1619347 protein_coding
  ENST00000592395 TCF3-012 1609291-1615798 nonsense_mediated_decay
  ENST00000592628 TCF3-006 1609293-1619135 protein_coding
  ENST00000593064 TCF3-014 1609293-1619209 protein_coding
  ENST00000610756 TCF3-010 1611687-1622236 retained_intron
  ENST00000611869 TCF3-001 1609293-1650278 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262965ENST00000344749ENST00000395423ENST00000453954ENST00000585731ENST00000586410ENST00000587235ENST00000587425ENST00000588136ENST00000590436ENST00000590684ENST00000592395ENST00000592628ENST00000593064ENST00000610756ENST00000611869
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262965 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.658±0.00 N/A N/A 2.725±0.00 N/A
ENST00000344749 3.938±0.00 4.367±0.00 N/A 1.772±0.00 8.510±0.00 4.395±0.00 0.508±0.00 N/A 0.783±0.00 5.128±0.00 N/A 8.790±8.46 4.077±0.69 19.273±0.00
ENST00000395423 N/A N/A N/A N/A N/A 0.568±0.00 N/A N/A N/A N/A N/A 13.371±0.00 5.129±0.00 34.128±0.00
ENST00000453954 N/A 6.955±0.00 N/A N/A N/A N/A N/A 1.427±0.96 0.997±0.00 0.296±0.00 N/A 13.073±5.23 N/A N/A
ENST00000585731 4.806±0.00 N/A N/A N/A N/A N/A 0.308±0.00 N/A 1.558±0.00 7.059±0.00 N/A N/A N/A N/A
ENST00000586410 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.532±0.00 N/A N/A
ENST00000587235 N/A N/A 2.073±0.00 N/A 4.988±0.00 N/A 2.061±0.00 N/A 2.295±0.00 1.491±0.00 N/A 2.244±0.00 N/A N/A
ENST00000587425 N/A N/A N/A 7.037±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000588136 N/A N/A 0.463±0.00 N/A 0.937±0.00 N/A N/A N/A N/A N/A N/A 0.418±0.00 N/A N/A
ENST00000590436 N/A N/A N/A N/A N/A 10.262±0.00 N/A 7.033±0.00 2.551±0.00 N/A N/A 32.353±0.00 16.998±0.00 55.496±5.94
ENST00000590684 N/A N/A 1.084±0.00 0.785±0.00 0.975±0.00 1.099±0.00 1.017±0.75 0.865±0.00 N/A N/A 4.297±3.49 N/A 6.300±0.00 N/A
ENST00000592395 N/A N/A N/A 0.472±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000592628 N/A N/A N/A N/A N/A N/A N/A 0.426±0.00 N/A N/A N/A N/A N/A N/A
ENST00000593064 N/A N/A N/A N/A 0.423±0.00 N/A N/A N/A N/A N/A N/A 12.247±0.00 5.012±0.00 22.466±0.00
ENST00000610756 12.971±0.00 N/A N/A N/A N/A 1.272±0.00 0.638±0.00 0.799±0.00 N/A N/A N/A N/A N/A 57.224±0.00
ENST00000611869 N/A 8.308±0.00 N/A N/A N/A 2.701±0.00 1.318±0.00 3.173±0.00 N/A N/A 2.297±0.00 9.929±0.00 3.499±0.79 15.919±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BR CIL_0004BR_0001 CGP 19:1597172-1652605
CIL_000188 CIL_000188_0001 CGP 19:1609290-1780988

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000788 IEA nuclear nucleosome
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001779 IEA natural killer cell differentiation
GO:0002326 NAS B cell lineage commitment
GO:0003677 IDA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IDA transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0010628 IEA positive regulation of gene expression
GO:0030098 IEA lymphocyte differentiation
GO:0030183 NAS B cell differentiation
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0032496 IEA response to lipopolysaccharide
GO:0033077 IEA T cell differentiation in thymus
GO:0033152 IDA immunoglobulin V(D)J recombination
GO:0035326 IC enhancer binding
GO:0042493 IEA response to drug
GO:0042692 TAS muscle cell differentiation
GO:0042803 IDA protein homodimerization activity
GO:0043234 IDA protein complex
GO:0043425 IPI bHLH transcription factor binding
GO:0043565 IDA sequence-specific DNA binding
GO:0043966 IEA histone H3 acetylation
GO:0043967 IEA histone H4 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045787 IDA positive regulation of cell cycle
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048468 IEA cell development
GO:0048541 IEA Peyer's patch development
GO:0050821 IEA protein stabilization
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0070491 IPI repressing transcription factor binding
GO:0070644 IDA vitamin D response element binding
GO:0070888 IDA E-box binding
GO:2000045 IDA regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005915 tcf3a transcription factor 3a protein_coding Danio_rerio
ENSDARG00000052383 tcf3b transcription factor 3b protein_coding Danio_rerio
ENSMUSG00000020167 Tcf3 transcription factor 3 protein_coding Mus_musculus

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