C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tumor protein p63
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000073282 TP63 9606 + 3:189631416-189897279 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264731 TP63-001 189631427-189897279 protein_coding
  ENST00000320472 TP63-003 189631488-189894702 protein_coding
  ENST00000354600 TP63-004 189789660-189897268 protein_coding
  ENST00000392460 TP63-010 189631516-189894221 protein_coding
  ENST00000392461 TP63-015 189789801-189894231 protein_coding
  ENST00000392463 TP63-011 189789801-189894221 protein_coding
  ENST00000418709 TP63-002 189631488-189881496 protein_coding
  ENST00000434928 TP63-007 189789675-189864268 protein_coding
  ENST00000437221 TP63-009 189789801-189881496 protein_coding
  ENST00000440651 TP63-008 189631516-189894502 protein_coding
  ENST00000449992 TP63-012 189789801-189894502 protein_coding
  ENST00000456148 TP63-013 189789801-189894502 protein_coding
  ENST00000460036 TP63-005 189789695-189873575 retained_intron
  ENST00000486398 TP63-006 189631416-189738896 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264731ENST00000320472ENST00000354600ENST00000392461ENST00000418709ENST00000434928ENST00000437221ENST00000440651ENST00000449992ENST00000456148ENST00000460036
Transcript ID Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264731 N/A N/A 0.446±0.00 N/A N/A N/A N/A N/A N/A N/A 1.046±0.07
ENST00000320472 0.072±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000354600 N/A 0.011±0.00 2.347±0.00 0.018±0.00 0.066±0.00 0.511±0.51 0.749±0.00 N/A 1.544±0.60 2.444±1.07 1.399±0.00
ENST00000392461 N/A 0.069±0.00 N/A N/A 0.088±0.00 2.729±0.00 N/A N/A N/A N/A N/A
ENST00000418709 N/A N/A N/A N/A N/A N/A N/A 5.102±0.00 N/A N/A N/A
ENST00000434928 0.533±0.00 0.348±0.00 N/A N/A N/A 6.637±0.00 N/A N/A 2.236±0.00 N/A N/A
ENST00000437221 N/A N/A N/A N/A N/A N/A N/A 6.812±6.10 N/A N/A N/A
ENST00000440651 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.238±0.00
ENST00000449992 N/A 0.253±0.00 N/A 0.193±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000456148 N/A N/A N/A N/A N/A N/A N/A 1.305±0.00 1.232±0.00 2.681±0.00 N/A
ENST00000460036 N/A N/A N/A N/A N/A N/A N/A N/A 0.599±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003Y5 CIL_0003Y5_0002 CGP 3:188947214-189897279
CIL_000933 CIL_000933_0001 VISTA 3:189215860-189816512
CIL_0000DP CIL_0000DP_0001 CGP 3:189631416-190122437

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IBA negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IBA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000989 IEA transcription factor binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001302 IEA replicative cell aging
GO:0001501 IEA skeletal system development
GO:0001736 IEA establishment of planar polarity
GO:0001738 IEA morphogenesis of a polarized epithelium
GO:0001942 IEA hair follicle development
GO:0002039 IBA p53 binding
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002064 IEA epithelial cell development
GO:0003677 NAS DNA binding
GO:0003682 IBA chromatin binding
GO:0003684 IBA damaged DNA binding
GO:0003690 IBA double-stranded DNA binding
GO:0003700 IBA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IBA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005791 IEA rough endoplasmic reticulum
GO:0005829 IBA cytosol
GO:0006338 IEA chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006915 TAS apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006978 IBA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219 IEA Notch signaling pathway
GO:0007283 IEA spermatogenesis
GO:0007389 IEA pattern specification process
GO:0007499 IEA ectoderm and mesoderm interaction
GO:0007569 IEA cell aging
GO:0008544 IEA epidermis development
GO:0009887 IEA organ morphogenesis
GO:0009954 IEA proximal/distal pattern formation
GO:0010165 IBA response to X-ray
GO:0010259 IEA multicellular organismal aging
GO:0010332 IBA response to gamma radiation
GO:0010481 IEA epidermal cell division
GO:0010482 ISS regulation of epidermal cell division
GO:0010838 IEA positive regulation of keratinocyte proliferation
GO:0019904 IEA protein domain specific binding
GO:0030154 IEA cell differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030326 IEA embryonic limb morphogenesis
GO:0030425 IBA dendrite
GO:0030850 IEA prostate gland development
GO:0030855 IEA epithelial cell differentiation
GO:0030859 IEA polarized epithelial cell differentiation
GO:0031069 IEA hair follicle morphogenesis
GO:0031571 IBA mitotic G1 DNA damage checkpoint
GO:0034644 IBA cellular response to UV
GO:0036342 IEA post-anal tail morphogenesis
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042771 IBA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523 IBA regulation of neuron apoptotic process
GO:0043565 IBA sequence-specific DNA binding
GO:0043589 IEA skin morphogenesis
GO:0043616 IEA keratinocyte proliferation
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045617 IEA negative regulation of keratinocyte differentiation
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048485 IEA sympathetic nervous system development
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048745 IEA smooth muscle tissue development
GO:0048807 IEA female genitalia morphogenesis
GO:0050699 IPI WW domain binding
GO:0051262 IEA protein tetramerization
GO:0051289 IPI protein homotetramerization
GO:0051402 IEA neuron apoptotic process
GO:0060157 IEA urinary bladder development
GO:0060197 IEA cloacal septation
GO:0060513 IEA prostatic bud formation
GO:0060529 IEA squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 ISS establishment of skin barrier
GO:1902808 IMP positive regulation of cell cycle G1/S phase transition
GO:2000271 IDA positive regulation of fibroblast apoptotic process
GO:2000381 IEA negative regulation of mesoderm development
GO:2000773 IMP negative regulation of cellular senescence
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044356 tp63 tumor protein p63 protein_coding Danio_rerio
ENSMUSG00000022510 Trp63 transformation related protein 63 protein_coding Mus_musculus

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